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ENZYME entry: EC 3.4.23.31

Accepted Name
scytalidopepsin A.
Alternative Name(s)
Scytalidium aspartic proteinase A.
Reaction catalysed
Hydrolysis of proteins with specificity similar to that of pepsin A, but also cleaves 7-Cys(SO3H)-|-Gly-8 and 17-Leu-|-Val-18 in the B chain of insulin
Comment(s)
  • Isolated from the imperfect fungus Scytalidium lignicolum.
  • Not inhibited by pepstatin-Ac, methyl 2-diazoacetamidohexanoate or 1,2-epoxy-3-(p-nitrophenyl)propane.
  • A related enzyme from the same organism, proteinase C, is also insensitive to these inhibitors and has molecular weight 406 kDa.
Cross-references
BRENDA3.4.23.31
EC2PDB3.4.23.31
ExplorEnz3.4.23.31
PRIAM enzyme-specific profiles3.4.23.31
KEGG Ligand Database for Enzyme Nomenclature3.4.23.31
IUBMB Enzyme Nomenclature3.4.23.31
IntEnz3.4.23.31
MEDLINEFind literature relating to 3.4.23.31
MetaCyc3.4.23.31
Rhea expert-curated reactions3.4.23.31

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.23.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-