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ENZYME entry: EC 3.4.23.31
Accepted Name |
scytalidopepsin A.
|
Alternative Name(s) |
Scytalidium aspartic proteinase A. |
Reaction catalysed |
Hydrolysis of proteins with specificity similar to that of pepsin A, but also cleaves 7-Cys(SO3H)-|-Gly-8 and 17-Leu-|-Val-18 in the B chain of insulin |
Comment(s) |
- Isolated from the imperfect fungus Scytalidium lignicolum.
- Not inhibited by pepstatin-Ac, methyl 2-diazoacetamidohexanoate or
1,2-epoxy-3-(p-nitrophenyl)propane.
- A related enzyme from the same organism, proteinase C, is also
insensitive to these inhibitors and has molecular weight 406 kDa.
|
Cross-references |
BRENDA | 3.4.23.31 |
EC2PDB | 3.4.23.31 |
ExplorEnz | 3.4.23.31 |
PRIAM enzyme-specific profiles | 3.4.23.31 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.23.31 |
IUBMB Enzyme Nomenclature | 3.4.23.31 |
IntEnz | 3.4.23.31 |
MEDLINE | Find literature relating to 3.4.23.31 |
MetaCyc | 3.4.23.31 |
Rhea expert-curated reactions | 3.4.23.31 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.23.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-