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ENZYME entry: EC

Accepted Name
scytalidopepsin B
Alternative Name(s)
Scytalidium aspartic proteinase B
Reaction catalysed
Hydrolysis of proteins with broad specificity, cleaving 24-Phe-|-Phe-25, but not 15-Leu-|-Tyr-16 and 25-Phe-|-Tyr-26 in the B chain of insulin
  • Isolated from the imperfect fungus Scytalidium lignicolum.
  • A second endopeptidase from S.lignicolum (see scytalidopepsin A) that is insensitive to pepstatin and methyl 2-diazoacetamidohexanoate.
  • 1,2-epoxy-3-(p-nitrophenoxy)propane reacts with Glu-53, which replaces one of the aspartic residues at the active center.
  • One of the smallest aspartic endopeptidases active as the monomer, with molecular weight 22 kDa.
  • Similarly inhibitor-resistant endopeptidases are found in the basidiomycetes Lentinus edodes and Ganoderma lucidum, and in Polyporus tulipiferae (a second endopeptidase distinct from polyporopepsin), but these are of typical aspartic endopeptidase size.
  • Belongs to peptidase family G1.
PRIAM enzyme-specific profiles3.4.23.32
KEGG Ligand Database for Enzyme Nomenclature3.4.23.32
IUBMB Enzyme Nomenclature3.4.23.32
MEDLINEFind literature relating to
Rhea expert-curated reactions3.4.23.32

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