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ENZYME

ENZYME entry: EC 3.4.23.36

Accepted Name
signal peptidase II
Alternative Name(s)
bacterial leader peptidase I
lipoprotein signal peptidase
premurein-leader peptidase
prolipoprotein-signal peptidase
SPase II
Reaction catalysed
Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains
Comment(s)
  • Inhibited by pepstatin and the antibiotic globomycin.
  • Belongs to peptidase family A8.
  • Formerly EC 3.4.99.35.
Cross-references
BRENDA3.4.23.36
EC2PDB3.4.23.36
ExplorEnz3.4.23.36
KEGG Ligand Database for Enzyme Nomenclature3.4.23.36
IUBMB Enzyme Nomenclature3.4.23.36
MEDLINEFind literature relating to 3.4.23.36
MetaCyc3.4.23.36
Rhea expert-curated reactions3.4.23.36
UniProtKB/Swiss-Prot
B0C3E3, LSPA_ACAM1A3DDW4, LSPA_ACET2Q6FG03, LSPA_ACIAD
B7H305, LSPA_ACIB3B0VMM0, LSPA_ACIBSA3M0S2, LSPA_ACIBT
A6VQH9, LSPA_ACTSZA0KG40, LSPA_AERHHB9JZH6, LSPA_ALLAM
B4RVP1, LSPA_ALTMDB3EU56, LSPA_AMOA5A7H688, LSPA_ANADF
B9KGU3, LSPA_ANAMFQ5P9U0, LSPA_ANAMMQ2GIV1, LSPA_ANAPZ
B7GFB0, LSPA_ANOFWO67692, LSPA_AQUAEA1K4R6, LSPA_AZOSB
C3P663, LSPA_BACAAC3L732, LSPA_BACACQ81WE6, LSPA_BACAN
B7JJY0, LSPA_BACC0Q732H6, LSPA_BACC1B7IUQ3, LSPA_BACC2
C1EPQ7, LSPA_BACC3B7H6M9, LSPA_BACC4B7HLM7, LSPA_BACC7
A7GRL8, LSPA_BACCNB9IVX0, LSPA_BACCQQ636D3, LSPA_BACCZ
Q6HES1, LSPA_BACHKA9VTD3, LSPA_BACMKA8FD10, LSPA_BACP2
Q45479, LSPA_BACSUA7Z4G5, LSPA_BACVZA1UUG9, LSPA_BARBK
Q6G5A2, LSPA_BARHEQ6G1A8, LSPA_BARQUA9IL10, LSPA_BART1
B2II67, LSPA_BEII9A1A2I0, LSPA_BIFAAB3DQ87, LSPA_BIFLD
Q8G7W3, LSPA_BIFLOB7GQ27, LSPA_BIFLSQ7VQK9, LSPA_BLOFL
Q493S2, LSPA_BLOPBQ0SN37, LSPA_BORAPO51425, LSPA_BORBU
B7J235, LSPA_BORBZB5RM28, LSPA_BORDLQ661F0, LSPA_BORGP
B2S0H3, LSPA_BORHDB5RRS4, LSPA_BORRAA1QZQ6, LSPA_BORT9
C0ZG49, LSPA_BREBNB2S8E3, LSPA_BRUA1Q2YNY8, LSPA_BRUA2
Q57FM7, LSPA_BRUABA9M794, LSPA_BRUC2C0RGK4, LSPA_BRUMB
Q8YES8, LSPA_BRUMEA5VN85, LSPA_BRUO2B0CIQ7, LSPA_BRUSI
Q8G308, LSPA_BRUSUB8D8U9, LSPA_BUCA5P57248, LSPA_BUCAI
Q8K9Z3, LSPA_BUCAPB8D753, LSPA_BUCATQ89AV0, LSPA_BUCBP
B1YVA5, LSPA_BURA4A0K9T6, LSPA_BURCHB4E8Z8, LSPA_BURCJ
Q0BCK7, LSPA_BURCMQ39DM7, LSPA_BURL3A9AGN5, LSPA_BURM1
A3MN08, LSPA_BURM7A2S502, LSPA_BURM9Q62HL3, LSPA_BURMA
A1V6V3, LSPA_BURMSB1JXC4, LSPA_BURO0Q1BUA0, LSPA_BURO1
A3NSD0, LSPA_BURP0Q3JV70, LSPA_BURP1A3N6P6, LSPA_BURP6
Q63WI4, LSPA_BURPSQ2T0H4, LSPA_BURTAA4JH33, LSPA_BURVG
B9MS17, LSPA_CALBDQ8R9R0, LSPA_CALS4A8FKE9, LSPA_CAMJ8
A7H513, LSPA_CAMJDQ0PBE9, LSPA_CAMJEA1VY81, LSPA_CAMJJ
Q5HWA6, LSPA_CAMJRQ9AAA6, LSPA_CAUVCB3PE13, LSPA_CELJU
Q5L6Q8, LSPA_CHLABQ3AQW9, LSPA_CHLCHQ824E2, LSPA_CHLCV
Q253G9, LSPA_CHLFFB3EEM7, LSPA_CHLL2Q3B5L1, LSPA_CHLL3
Q9PJY8, LSPA_CHLMUB3QQ42, LSPA_CHLP8B3ELA5, LSPA_CHLPB
A1BED5, LSPA_CHLPDA4SDK1, LSPA_CHLPMQ9Z817, LSPA_CHLPN
B0B7X8, LSPA_CHLT2Q3KLU5, LSPA_CHLTAB0BC43, LSPA_CHLTB
Q8KBH7, LSPA_CHLTEO84413, LSPA_CHLTRQ7NS58, LSPA_CHRVO
A8ALT5, LSPA_CITK8Q97H98, LSPA_CLOABQ182T8, LSPA_CLOD6
A0Q072, LSPA_CLONNQ894D4, LSPA_CLOTEA9KEI7, LSPA_COXBN
A9NBM6, LSPA_COXBRQ83EC8, LSPA_COXBUA7MIM2, LSPA_CROS8
Q0K799, LSPA_CUPNHQ46XM6, LSPA_CUPPJB3R6E9, LSPA_CUPTR
B8HXG1, LSPA_CYAP4Q3Z6R4, LSPA_DEHM1A5FPV7, LSPA_DEHMB
Q3ZYT1, LSPA_DEHMCQ9RRU7, LSPA_DEIRAC0QGT5, LSPA_DESAH
B8FT17, LSPA_DESHDQ24TI7, LSPA_DESHYQ6AK46, LSPA_DESPS
A5EWT1, LSPA_DICNVA7ZHB6, LSPA_ECO24B7UI72, LSPA_ECO27
B7MAE7, LSPA_ECO45B7L4E9, LSPA_ECO55Q8XA48, LSPA_ECO57
B5YYB9, LSPA_ECO5EB7NHD1, LSPA_ECO7IB7MNN2, LSPA_ECO81
B7M0C3, LSPA_ECO8AC4ZPV3, LSPA_ECOBWB1XBF2, LSPA_ECODH
A7ZVX5, LSPA_ECOHSA1A775, LSPA_ECOK1Q0TLW4, LSPA_ECOL5
Q8FLB6, LSPA_ECOL6B1IRE8, LSPA_ECOLCP00804, LSPA_ECOLI
B7N7Q1, LSPA_ECOLUB6HZ22, LSPA_ECOSEB1LFV7, LSPA_ECOSM
Q1RGH5, LSPA_ECOUTA4XQV6, LSPA_ECTM1A4W6E2, LSPA_ENT38
Q834D8, LSPA_ENTFAB2VH02, LSPA_ERWT9B7LVN3, LSPA_ESCF3
Q14HT3, LSPA_FRAT1Q2A4Z5, LSPA_FRATHB2SF87, LSPA_FRATM
A0Q528, LSPA_FRATNQ0BNB6, LSPA_FRATOQ5NGD1, LSPA_FRATT
Q8RH46, LSPA_FUSNNQ5L0V0, LSPA_GEOKAQ39YS9, LSPA_GEOMG
Q747Y0, LSPA_GEOSLA4IM26, LSPA_GEOTNB7KFK1, LSPA_GLOC7
Q7NPI3, LSPA_GLOVIQ7VPK5, LSPA_HAEDUQ4QLQ6, LSPA_HAEI8
A5UID8, LSPA_HAEIGP44975, LSPA_HAEINQ9K9V2, LSPA_HALH5
B8CWL9, LSPA_HALOHQ17VS8, LSPA_HELAHB6JPH7, LSPA_HELP2
Q1CV80, LSPA_HELPHQ9ZMZ3, LSPA_HELPJB2UW72, LSPA_HELPS
P25178, LSPA_HELPYQ0I1V9, LSPA_HISS1B0UV09, LSPA_HISS2
Q31ID1, LSPA_HYDCUA6SW70, LSPA_JANMAP13514, LSPA_KLEAK
B5Y234, LSPA_KLEP3A6T4G1, LSPA_KLEP7Q043I1, LSPA_LACGA
Q74JC2, LSPA_LACJOQ9CGU5, LSPA_LACLAQ48729, LSPA_LACLM
Q02ZK6, LSPA_LACLSQ88W75, LSPA_LACPLQ38X31, LSPA_LATSS
Q6AE72, LSPA_LEIXXB0S977, LSPA_LEPBAQ04QT4, LSPA_LEPBJ
Q053U5, LSPA_LEPBLB0SRR1, LSPA_LEPBPQ72PS8, LSPA_LEPIC
Q8F6H0, LSPA_LEPINQ1WTX7, LSPA_LIGS1Q92AG4, LSPA_LISIN
C1KWE3, LSPA_LISMCQ71YH2, LSPA_LISMFB8DDQ9, LSPA_LISMH
Q8Y656, LSPA_LISMOA0AJU9, LSPA_LISW6Q8EWS0, LSPA_MALP2
C6BV90, LSPA_MARSDA9W565, LSPA_METEPB8IB41, LSPA_METNO
A2SKB1, LSPA_METPPB1LSB3, LSPA_METRJB0UDF9, LSPA_METS4
B8ETD6, LSPA_METSBB0JFT3, LSPA_MICANQ2RK54, LSPA_MOOTA
A0QHM5, LSPA_MYCA1P65263, LSPA_MYCBOA1KIW9, LSPA_MYCBP
Q7NBQ3, LSPA_MYCGAQ49401, LSPA_MYCGEB8ZR76, LSPA_MYCLB
Q9X7E7, LSPA_MYCLEP75484, LSPA_MYCPNA0QX51, LSPA_MYCS2
P9WK98, LSPA_MYCTOP9WK99, LSPA_MYCTUB2A2J1, LSPA_NATTJ
Q5FAF3, LSPA_NEIG1A9M1J8, LSPA_NEIM0P65264, LSPA_NEIMA
P65265, LSPA_NEIMBA1KS63, LSPA_NEIMFQ1QIP9, LSPA_NITHX
Q72AR4, LSPA_NITV2A1VCU2, LSPA_NITV4B2IU55, LSPA_NOSP7
Q8YNI8, LSPA_NOSS1Q8ER40, LSPA_OCEIHQ30ZF6, LSPA_OLEA2
A5CFG7, LSPA_ORITBB3CS08, LSPA_ORITIQ7U7A6, LSPA_PARMW
B2JDY8, LSPA_PARP8B2T6I8, LSPA_PARPJP57959, LSPA_PASMU
B4SD15, LSPA_PELPBA5D178, LSPA_PELTSQ4FPB0, LSPA_PELUB
Q7N8X1, LSPA_PHOLLB1XW26, LSPA_POLNSQ125P4, LSPA_POLSJ
B2RI39, LSPA_PORG3Q7MUD1, LSPA_PORGIQ15R05, LSPA_PSEA6
A6VBU6, LSPA_PSEA7Q02GB8, LSPA_PSEABQ9HVM5, LSPA_PSEAE
Q4K5U5, LSPA_PSEF5P17942, LSPA_PSEFLQ3K6L6, LSPA_PSEPF
Q88Q91, LSPA_PSEPKQ889E3, LSPA_PSESMQ3IEA1, LSPA_PSET1
A1SZP2, LSPA_PSYINQ8XWL5, LSPA_RALN1Q98GR1, LSPA_RHILO
Q92SJ3, LSPA_RHIMEA5VCW2, LSPA_RHIWRQ7UF32, LSPA_RHOBA
Q0SHT6, LSPA_RHOJRQ6N1M9, LSPA_RHOPAB3Q7Z4, LSPA_RHOPT
C3PND1, LSPA_RICAEA8GNC3, LSPA_RICAHA8GVJ0, LSPA_RICB8
Q1RI47, LSPA_RICBRA8EZ20, LSPA_RICCKQ92I62, LSPA_RICCN
Q4ULU0, LSPA_RICFEQ9ZDC4, LSPA_RICPRQ68WX1, LSPA_RICTY
B5F725, LSPA_SALA4A9MR45, LSPA_SALARQ57TL4, LSPA_SALCH
B5FHE1, LSPA_SALDCB5R1N7, LSPA_SALEPB5RG82, LSPA_SALG2
B4TIE6, LSPA_SALHSB4T6H3, LSPA_SALNSQ5PDL8, LSPA_SALPA
C0Q4I6, LSPA_SALPCB5BLL1, LSPA_SALPKB4TWN7, LSPA_SALSV
Q8Z9N1, LSPA_SALTIQ8ZRY9, LSPA_SALTYO52213, LSPA_SERMA
A8G9L5, LSPA_SERP5A1S426, LSPA_SHEAMB8EFC6, LSPA_SHEB2
A3D1G6, LSPA_SHEB5A6WKD5, LSPA_SHEB8A9L4U8, LSPA_SHEB9
B0TJB0, LSPA_SHEHHA3QBX3, LSPA_SHELPQ8EBI5, LSPA_SHEON
A8H1H4, LSPA_SHEPAB8CSC0, LSPA_SHEPWA8FSI3, LSPA_SHESH
Q0HFZ0, LSPA_SHESMQ0HS83, LSPA_SHESRB1KIT6, LSPA_SHEWM
B2U246, LSPA_SHIB3Q326J6, LSPA_SHIBSQ32K70, LSPA_SHIDS
Q0T8G7, LSPA_SHIF8Q83MH1, LSPA_SHIFLQ3Z5Y3, LSPA_SHISS
Q5WFI5, LSPA_SHOC1C3MEK8, LSPA_SINFNQ2NVY5, LSPA_SODGM
Q01VL4, LSPA_SOLUEQ1GQK7, LSPA_SPHALA7X1E3, LSPA_STAA1
A6U115, LSPA_STAA2Q2FHP2, LSPA_STAA3Q2FZ79, LSPA_STAA8
A5IS81, LSPA_STAA9Q2YXH2, LSPA_STAABQ5HGN6, LSPA_STAAC
A6QG97, LSPA_STAAEP65266, LSPA_STAAMP65267, LSPA_STAAN
Q6GHN9, LSPA_STAARQ6GA17, LSPA_STAASA8Z3N3, LSPA_STAAT
P31024, LSPA_STAAUP65268, LSPA_STAAWQ59835, LSPA_STACT
Q5HPZ5, LSPA_STAEQQ8CPK0, LSPA_STAESQ4L5P8, LSPA_STAHJ
Q3K0E6, LSPA_STRA1Q8E4G5, LSPA_STRA3Q8DYV7, LSPA_STRA5
Q82AC7, LSPA_STRAWQ9S2X7, LSPA_STRCOB1W0K0, LSPA_STRGG
Q8DUQ0, LSPA_STRMUQ9A0D2, LSPA_STRP1P0DC20, LSPA_STRP3
Q5XCS3, LSPA_STRP6Q8P1G4, LSPA_STRP8Q1JCF3, LSPA_STRPB
Q1JMD2, LSPA_STRPCQ1JHH8, LSPA_STRPDQ1J798, LSPA_STRPF
A2RF66, LSPA_STRPGQ48U75, LSPA_STRPMP0DC21, LSPA_STRPQ
Q8DQ64, LSPA_STRR6Q5M0X5, LSPA_STRT1Q5M5G2, LSPA_STRT2
Q03LU4, LSPA_STRTDQ30NW9, LSPA_SULDNA6Q6B7, LSPA_SULNB
B2V758, LSPA_SULSYQ67Q16, LSPA_SYMTHQ2LTG5, LSPA_SYNAS
Q3A1R4, LSPA_SYNC1A5GTI3, LSPA_SYNR3Q0AXF8, LSPA_SYNWW
P73540, LSPA_SYNY3C5BQX3, LSPA_TERTTQ8DGA3, LSPA_THEVB
B5YJT2, LSPA_THEYDC4LD11, LSPA_TOLATQ73JG0, LSPA_TREDE
O83943, LSPA_TREPAQ3MA96, LSPA_TRIV2Q83I41, LSPA_TROW8
Q83G22, LSPA_TROWTA7MTD7, LSPA_VIBC1A5F8Z4, LSPA_VIBC3
Q9KU46, LSPA_VIBCHC3LST8, LSPA_VIBCMQ87S89, LSPA_VIBPA
Q8DES8, LSPA_VIBVUQ7MNM7, LSPA_VIBVYQ8D2R1, LSPA_WIGBR
Q7M9M1, LSPA_WOLSUQ8PN18, LSPA_XANACQ4US41, LSPA_XANC8
Q8PBG5, LSPA_XANCPQ3BW41, LSPA_XANE5Q2P5A9, LSPA_XANOM
B2STC5, LSPA_XANOPQ5H2E0, LSPA_XANORB2I6V1, LSPA_XYLF2
Q9PAS8, LSPA_XYLFAB0U3Q8, LSPA_XYLFMQ87BL6, LSPA_XYLFT
A1JJE2, LSPA_YERE8A7FMD6, LSPA_YERP3Q1C0J2, LSPA_YERPA
B2K3M7, LSPA_YERPBQ8ZIL9, LSPA_YERPEA9R007, LSPA_YERPG
Q1CMV0, LSPA_YERPNA4TQF2, LSPA_YERPPQ66ES3, LSPA_YERPS
B1JKZ7, LSPA_YERPY

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