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ENZYME

ENZYME entry: EC 3.4.23.36

Accepted Name
signal peptidase II
Alternative Name(s)
bacterial leader peptidase I
lipoprotein signal peptidase
premurein-leader peptidase
prolipoprotein-signal peptidase
SPase II
Reaction catalysed
Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains
Comment(s)
  • Inhibited by pepstatin and the antibiotic globomycin.
  • Belongs to peptidase family A8.
  • Formerly EC 3.4.99.35.
Cross-references
BRENDA3.4.23.36
EC2PDB3.4.23.36
ExplorEnz3.4.23.36
PRIAM enzyme-specific profiles3.4.23.36
KEGG Ligand Database for Enzyme Nomenclature3.4.23.36
IUBMB Enzyme Nomenclature3.4.23.36
IntEnz3.4.23.36
MEDLINEFind literature relating to 3.4.23.36
MetaCyc3.4.23.36
Rhea expert-curated reactions3.4.23.36
UniProtKB/Swiss-Prot
B0C3E3, LSPA_ACAM1A3DDW4, LSPA_ACET2Q6FG03, LSPA_ACIAD
B7H305, LSPA_ACIB3B0VMM0, LSPA_ACIBSA3M0S2, LSPA_ACIBT
A6VQH9, LSPA_ACTSZA0KG40, LSPA_AERHHQ5WFI5, LSPA_ALKCK
B9JZH6, LSPA_ALLAMB4RVP1, LSPA_ALTMDB3EU56, LSPA_AMOA5
A7H688, LSPA_ANADFB9KGU3, LSPA_ANAMFQ5P9U0, LSPA_ANAMM
Q2GIV1, LSPA_ANAPZB7GFB0, LSPA_ANOFWO67692, LSPA_AQUAE
A1K4R6, LSPA_AZOSBC3P663, LSPA_BACAAC3L732, LSPA_BACAC
Q81WE6, LSPA_BACANB7JJY0, LSPA_BACC0Q732H6, LSPA_BACC1
B7IUQ3, LSPA_BACC2C1EPQ7, LSPA_BACC3B7H6M9, LSPA_BACC4
B7HLM7, LSPA_BACC7A7GRL8, LSPA_BACCNB9IVX0, LSPA_BACCQ
Q636D3, LSPA_BACCZQ6HES1, LSPA_BACHKA9VTD3, LSPA_BACMK
A8FD10, LSPA_BACP2Q45479, LSPA_BACSUA7Z4G5, LSPA_BACVZ
A1UUG9, LSPA_BARBKQ6G5A2, LSPA_BARHEQ6G1A8, LSPA_BARQU
A9IL10, LSPA_BART1B2II67, LSPA_BEII9A1A2I0, LSPA_BIFAA
B3DQ87, LSPA_BIFLDQ8G7W3, LSPA_BIFLOB7GQ27, LSPA_BIFLS
Q7VQK9, LSPA_BLOFLQ493S2, LSPA_BLOPBQ0SN37, LSPA_BORAP
O51425, LSPA_BORBUB7J235, LSPA_BORBZB5RM28, LSPA_BORDL
Q661F0, LSPA_BORGPB2S0H3, LSPA_BORHDB5RRS4, LSPA_BORRA
A1QZQ6, LSPA_BORT9C0ZG49, LSPA_BREBNB2S8E3, LSPA_BRUA1
Q2YNY8, LSPA_BRUA2Q57FM7, LSPA_BRUABA9M794, LSPA_BRUC2
C0RGK4, LSPA_BRUMBQ8YES8, LSPA_BRUMEA5VN85, LSPA_BRUO2
B0CIQ7, LSPA_BRUSIQ8G308, LSPA_BRUSUB8D8U9, LSPA_BUCA5
P57248, LSPA_BUCAIQ8K9Z3, LSPA_BUCAPB8D753, LSPA_BUCAT
Q89AV0, LSPA_BUCBPB1YVA5, LSPA_BURA4A0K9T6, LSPA_BURCH
B4E8Z8, LSPA_BURCJQ0BCK7, LSPA_BURCMQ39DM7, LSPA_BURL3
A9AGN5, LSPA_BURM1A3MN08, LSPA_BURM7A2S502, LSPA_BURM9
Q62HL3, LSPA_BURMAA1V6V3, LSPA_BURMSB1JXC4, LSPA_BURO0
Q1BUA0, LSPA_BURO1A3NSD0, LSPA_BURP0Q3JV70, LSPA_BURP1
A3N6P6, LSPA_BURP6Q63WI4, LSPA_BURPSQ2T0H4, LSPA_BURTA
A4JH33, LSPA_BURVGB9MS17, LSPA_CALBDQ8R9R0, LSPA_CALS4
A8FKE9, LSPA_CAMJ8A7H513, LSPA_CAMJDQ0PBE9, LSPA_CAMJE
A1VY81, LSPA_CAMJJQ5HWA6, LSPA_CAMJRQ9AAA6, LSPA_CAUVC
B3PE13, LSPA_CELJUQ5L6Q8, LSPA_CHLABQ3AQW9, LSPA_CHLCH
Q824E2, LSPA_CHLCVQ253G9, LSPA_CHLFFB3EEM7, LSPA_CHLL2
Q3B5L1, LSPA_CHLL3Q9PJY8, LSPA_CHLMUB3QQ42, LSPA_CHLP8
B3ELA5, LSPA_CHLPBA1BED5, LSPA_CHLPDA4SDK1, LSPA_CHLPM
Q9Z817, LSPA_CHLPNB0B7X8, LSPA_CHLT2Q3KLU5, LSPA_CHLTA
B0BC43, LSPA_CHLTBQ8KBH7, LSPA_CHLTEO84413, LSPA_CHLTR
Q7NS58, LSPA_CHRVOA8ALT5, LSPA_CITK8Q97H98, LSPA_CLOAB
Q182T8, LSPA_CLOD6A0Q072, LSPA_CLONNQ894D4, LSPA_CLOTE
A9KEI7, LSPA_COXBNA9NBM6, LSPA_COXBRQ83EC8, LSPA_COXBU
A7MIM2, LSPA_CROS8Q0K799, LSPA_CUPNHQ46XM6, LSPA_CUPPJ
B3R6E9, LSPA_CUPTRB8HXG1, LSPA_CYAP4Q3Z6R4, LSPA_DEHM1
A5FPV7, LSPA_DEHMBQ3ZYT1, LSPA_DEHMCQ9RRU7, LSPA_DEIRA
C0QGT5, LSPA_DESAHB8FT17, LSPA_DESHDQ24TI7, LSPA_DESHY
Q6AK46, LSPA_DESPSQ72AR4, LSPA_DESVHA1VCU2, LSPA_DESVV
A5EWT1, LSPA_DICNVA7ZHB6, LSPA_ECO24B7UI72, LSPA_ECO27
B7MAE7, LSPA_ECO45B7L4E9, LSPA_ECO55Q8XA48, LSPA_ECO57
B5YYB9, LSPA_ECO5EB7NHD1, LSPA_ECO7IB7MNN2, LSPA_ECO81
B7M0C3, LSPA_ECO8AC4ZPV3, LSPA_ECOBWB1XBF2, LSPA_ECODH
A7ZVX5, LSPA_ECOHSA1A775, LSPA_ECOK1Q0TLW4, LSPA_ECOL5
Q8FLB6, LSPA_ECOL6B1IRE8, LSPA_ECOLCP00804, LSPA_ECOLI
B7N7Q1, LSPA_ECOLUB6HZ22, LSPA_ECOSEB1LFV7, LSPA_ECOSM
Q1RGH5, LSPA_ECOUTA4W6E2, LSPA_ENT38Q834D8, LSPA_ENTFA
B2VH02, LSPA_ERWT9B7LVN3, LSPA_ESCF3Q14HT3, LSPA_FRAT1
Q2A4Z5, LSPA_FRATHB2SF87, LSPA_FRATMA0Q528, LSPA_FRATN
Q0BNB6, LSPA_FRATOQ5NGD1, LSPA_FRATTQ8RH46, LSPA_FUSNN
Q5L0V0, LSPA_GEOKAQ39YS9, LSPA_GEOMGQ747Y0, LSPA_GEOSL
A4IM26, LSPA_GEOTNB7KFK1, LSPA_GLOC7Q7NPI3, LSPA_GLOVI
Q7VPK5, LSPA_HAEDUQ4QLQ6, LSPA_HAEI8A5UID8, LSPA_HAEIG
P44975, LSPA_HAEINQ9K9V2, LSPA_HALH5B8CWL9, LSPA_HALOH
Q17VS8, LSPA_HELAHB6JPH7, LSPA_HELP2Q1CV80, LSPA_HELPH
Q9ZMZ3, LSPA_HELPJB2UW72, LSPA_HELPSP25178, LSPA_HELPY
Q0I1V9, LSPA_HISS1B0UV09, LSPA_HISS2Q31ID1, LSPA_HYDCU
A6SW70, LSPA_JANMAP13514, LSPA_KLEAKB5Y234, LSPA_KLEP3
A6T4G1, LSPA_KLEP7Q043I1, LSPA_LACGAQ74JC2, LSPA_LACJO
Q9CGU5, LSPA_LACLAQ48729, LSPA_LACLMQ02ZK6, LSPA_LACLS
Q88W75, LSPA_LACPLQ38X31, LSPA_LATSSQ6AE72, LSPA_LEIXX
B0S977, LSPA_LEPBAQ04QT4, LSPA_LEPBJQ053U5, LSPA_LEPBL
B0SRR1, LSPA_LEPBPQ72PS8, LSPA_LEPICQ8F6H0, LSPA_LEPIN
Q1WTX7, LSPA_LIGS1Q92AG4, LSPA_LISINC1KWE3, LSPA_LISMC
Q71YH2, LSPA_LISMFB8DDQ9, LSPA_LISMHQ8Y656, LSPA_LISMO
A0AJU9, LSPA_LISW6Q8EWS0, LSPA_MALP2C6BV90, LSPA_MARSD
A9W565, LSPA_METEPB8IB41, LSPA_METNOA2SKB1, LSPA_METPP
B1LSB3, LSPA_METRJB0UDF9, LSPA_METS4B8ETD6, LSPA_METSB
B0JFT3, LSPA_MICANQ2RK54, LSPA_MOOTAA0QHM5, LSPA_MYCA1
P65263, LSPA_MYCBOA1KIW9, LSPA_MYCBPQ7NBQ3, LSPA_MYCGA
Q49401, LSPA_MYCGEB8ZR76, LSPA_MYCLBQ9X7E7, LSPA_MYCLE
P75484, LSPA_MYCPNA0QX51, LSPA_MYCS2P9WK98, LSPA_MYCTO
P9WK99, LSPA_MYCTUB2A2J1, LSPA_NATTJQ5FAF3, LSPA_NEIG1
A9M1J8, LSPA_NEIM0P65264, LSPA_NEIMAP65265, LSPA_NEIMB
A1KS63, LSPA_NEIMFQ1QIP9, LSPA_NITHXB2IU55, LSPA_NOSP7
Q8YNI8, LSPA_NOSS1Q8ER40, LSPA_OCEIHQ30ZF6, LSPA_OLEA2
A5CFG7, LSPA_ORITBB3CS08, LSPA_ORITIQ7U7A6, LSPA_PARMW
B2JDY8, LSPA_PARP8B2T6I8, LSPA_PARPJP57959, LSPA_PASMU
B4SD15, LSPA_PELPBA5D178, LSPA_PELTSQ4FPB0, LSPA_PELUB
Q7N8X1, LSPA_PHOLLB1XW26, LSPA_POLNSQ125P4, LSPA_POLSJ
B2RI39, LSPA_PORG3Q7MUD1, LSPA_PORGIQ15R05, LSPA_PSEA6
A6VBU6, LSPA_PSEA7Q02GB8, LSPA_PSEABQ9HVM5, LSPA_PSEAE
Q4K5U5, LSPA_PSEF5P17942, LSPA_PSEFLA4XQV6, LSPA_PSEMY
Q3K6L6, LSPA_PSEPFQ88Q91, LSPA_PSEPKQ889E3, LSPA_PSESM
Q3IEA1, LSPA_PSET1A1SZP2, LSPA_PSYINQ8XWL5, LSPA_RALN1
Q98GR1, LSPA_RHILOQ92SJ3, LSPA_RHIMEA5VCW2, LSPA_RHIWR
Q7UF32, LSPA_RHOBAQ0SHT6, LSPA_RHOJRQ6N1M9, LSPA_RHOPA
B3Q7Z4, LSPA_RHOPTC3PND1, LSPA_RICAEA8GNC3, LSPA_RICAH
A8GVJ0, LSPA_RICB8Q1RI47, LSPA_RICBRA8EZ20, LSPA_RICCK
Q92I62, LSPA_RICCNQ4ULU0, LSPA_RICFEQ9ZDC4, LSPA_RICPR
Q68WX1, LSPA_RICTYB5F725, LSPA_SALA4A9MR45, LSPA_SALAR
Q57TL4, LSPA_SALCHB5FHE1, LSPA_SALDCB5R1N7, LSPA_SALEP
B5RG82, LSPA_SALG2B4TIE6, LSPA_SALHSB4T6H3, LSPA_SALNS
Q5PDL8, LSPA_SALPAC0Q4I6, LSPA_SALPCB5BLL1, LSPA_SALPK
B4TWN7, LSPA_SALSVQ8Z9N1, LSPA_SALTIQ8ZRY9, LSPA_SALTY
O52213, LSPA_SERMAA8G9L5, LSPA_SERP5A1S426, LSPA_SHEAM
B8EFC6, LSPA_SHEB2A3D1G6, LSPA_SHEB5A6WKD5, LSPA_SHEB8
A9L4U8, LSPA_SHEB9B0TJB0, LSPA_SHEHHA3QBX3, LSPA_SHELP
Q8EBI5, LSPA_SHEONA8H1H4, LSPA_SHEPAB8CSC0, LSPA_SHEPW
A8FSI3, LSPA_SHESHQ0HFZ0, LSPA_SHESMQ0HS83, LSPA_SHESR
B1KIT6, LSPA_SHEWMB2U246, LSPA_SHIB3Q326J6, LSPA_SHIBS
Q32K70, LSPA_SHIDSQ0T8G7, LSPA_SHIF8Q83MH1, LSPA_SHIFL
Q3Z5Y3, LSPA_SHISSC3MEK8, LSPA_SINFNQ2NVY5, LSPA_SODGM
Q01VL4, LSPA_SOLUEQ1GQK7, LSPA_SPHALA7X1E3, LSPA_STAA1
A6U115, LSPA_STAA2Q2FHP2, LSPA_STAA3Q2FZ79, LSPA_STAA8
A5IS81, LSPA_STAA9Q2YXH2, LSPA_STAABQ5HGN6, LSPA_STAAC
A6QG97, LSPA_STAAEP65266, LSPA_STAAMP65267, LSPA_STAAN
Q6GHN9, LSPA_STAARQ6GA17, LSPA_STAASA8Z3N3, LSPA_STAAT
P31024, LSPA_STAAUP65268, LSPA_STAAWQ59835, LSPA_STACT
Q5HPZ5, LSPA_STAEQQ8CPK0, LSPA_STAESQ4L5P8, LSPA_STAHJ
Q3K0E6, LSPA_STRA1Q8E4G5, LSPA_STRA3Q8DYV7, LSPA_STRA5
Q82AC7, LSPA_STRAWQ9S2X7, LSPA_STRCOB1W0K0, LSPA_STRGG
Q8DUQ0, LSPA_STRMUQ9A0D2, LSPA_STRP1P0DC20, LSPA_STRP3
Q5XCS3, LSPA_STRP6Q8P1G4, LSPA_STRP8Q1JCF3, LSPA_STRPB
Q1JMD2, LSPA_STRPCQ1JHH8, LSPA_STRPDQ1J798, LSPA_STRPF
A2RF66, LSPA_STRPGQ48U75, LSPA_STRPMP0DC21, LSPA_STRPQ
Q8DQ64, LSPA_STRR6Q5M0X5, LSPA_STRT1Q5M5G2, LSPA_STRT2
Q03LU4, LSPA_STRTDQ30NW9, LSPA_SULDNA6Q6B7, LSPA_SULNB
B2V758, LSPA_SULSYQ67Q16, LSPA_SYMTHQ2LTG5, LSPA_SYNAS
Q3A1R4, LSPA_SYNC1A5GTI3, LSPA_SYNR3Q0AXF8, LSPA_SYNWW
P73540, LSPA_SYNY3C5BQX3, LSPA_TERTTQ8DGA3, LSPA_THEVB
B5YJT2, LSPA_THEYDC4LD11, LSPA_TOLATQ73JG0, LSPA_TREDE
O83943, LSPA_TREPAQ3MA96, LSPA_TRIV2Q83I41, LSPA_TROW8
Q83G22, LSPA_TROWTA7MTD7, LSPA_VIBC1A5F8Z4, LSPA_VIBC3
Q9KU46, LSPA_VIBCHC3LST8, LSPA_VIBCMQ87S89, LSPA_VIBPA
Q8DES8, LSPA_VIBVUQ7MNM7, LSPA_VIBVYQ8D2R1, LSPA_WIGBR
Q7M9M1, LSPA_WOLSUQ8PN18, LSPA_XANACQ3BW41, LSPA_XANC5
Q4US41, LSPA_XANC8Q8PBG5, LSPA_XANCPQ2P5A9, LSPA_XANOM
B2STC5, LSPA_XANOPQ5H2E0, LSPA_XANORB2I6V1, LSPA_XYLF2
Q9PAS8, LSPA_XYLFAB0U3Q8, LSPA_XYLFMQ87BL6, LSPA_XYLFT
A1JJE2, LSPA_YERE8A7FMD6, LSPA_YERP3Q1C0J2, LSPA_YERPA
B2K3M7, LSPA_YERPBQ8ZIL9, LSPA_YERPEA9R007, LSPA_YERPG
Q1CMV0, LSPA_YERPNA4TQF2, LSPA_YERPPQ66ES3, LSPA_YERPS
B1JKZ7, LSPA_YERPY

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