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ENZYME entry: EC 3.4.23.4

Accepted Name
Chymosin.
Alternative Name(s)
Rennin.
Reaction catalysed
Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single 104-Ser-Phe-|-Met-Ala-107 bond in kappa-chain of casein
Comment(s)
  • Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin.
  • Found among mammals with postnatal uptake of immunoglobins.
  • Belongs to peptidase family A1.
  • Formerly EC 3.4.4.3.
Cross-references
PROSITEPDOC00128
BRENDA3.4.23.4
EC2PDB3.4.23.4
ExplorEnz3.4.23.4
PRIAM enzyme-specific profiles3.4.23.4
KEGG Ligand Database for Enzyme Nomenclature3.4.23.4
IUBMB Enzyme Nomenclature3.4.23.4
IntEnz3.4.23.4
MEDLINEFind literature relating to 3.4.23.4
MetaCyc3.4.23.4
Rhea expert-curated reactions3.4.23.4
UniProtKB/Swiss-Prot
P00794, CHYM_BOVIN;  Q9N2D2, CHYM_CALJA;  Q9GK11, CHYM_CAMDR;  
P09873, CHYM_FELCA;  P18276, CHYM_SHEEP;  

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