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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.23.45

Accepted Name
Memapsin 1.
Alternative Name(s)
ASP1.
BACE2.
Beta-secretase.
Beta-site Alzheimer's amyloid precursor protein cleaving enzyme 2.
Beta-site APP-cleaving enzyme 2.
Down region aspartic protease.
Membrane-associated aspartic protease 1.
Reaction catalysed
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
Comment(s)
  • Can cleave beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease, but is not significantly expressed in human brain.
  • Belongs to peptidase family A1.
Cross-references
PROSITEPDOC00128
BRENDA3.4.23.45
EC2PDB3.4.23.45
ExplorEnz3.4.23.45
PRIAM enzyme-specific profiles3.4.23.45
KEGG Ligand Database for Enzyme Nomenclature3.4.23.45
IUBMB Enzyme Nomenclature3.4.23.45
IntEnz3.4.23.45
MEDLINEFind literature relating to 3.4.23.45
MetaCyc3.4.23.45
UniProtKB/Swiss-Prot
Q9Y5Z0, BACE2_HUMAN;  Q9JL18, BACE2_MOUSE;  Q6IE75, BACE2_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.23.-
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