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ENZYME

ENZYME entry: EC 3.4.23.45

Accepted Name
memapsin 1
Alternative Name(s)
ASP1
BACE2
beta-secretase
beta-site Alzheimer's amyloid precursor protein cleaving enzyme 2
beta-site APP-cleaving enzyme 2
Down region aspartic protease
membrane-associated aspartic protease 1
Reaction catalysed
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
Comment(s)
  • Can cleave beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease, but is not significantly expressed in human brain.
  • Belongs to peptidase family A1.
Cross-references
BRENDA3.4.23.45
EC2PDB3.4.23.45
ExplorEnz3.4.23.45
PRIAM enzyme-specific profiles3.4.23.45
KEGG Ligand Database for Enzyme Nomenclature3.4.23.45
IUBMB Enzyme Nomenclature3.4.23.45
IntEnz3.4.23.45
MEDLINEFind literature relating to 3.4.23.45
MetaCyc3.4.23.45
Rhea expert-curated reactions3.4.23.45
UniProtKB/Swiss-Prot
Q9Y5Z0, BACE2_HUMANQ9JL18, BACE2_MOUSEQ6IE75, BACE2_RAT

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