A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.23.45
| Accepted Name |
|---|
| Memapsin 1.
|
| Alternative Name(s) |
|---|
| ASP1. |
| BACE2. |
| Beta-secretase. |
| Beta-site Alzheimer's amyloid precursor protein cleaving enzyme 2. |
| Beta-site APP-cleaving enzyme 2. |
| Down region aspartic protease. |
| Membrane-associated aspartic protease 1. |
| Reaction catalysed |
|---|
| Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein |
| Comment(s) |
|---|
- Can cleave beta-amyloid precursor protein to form the amyloidogenic
beta-peptide that is implicated in the pathology of Alzheimer's
disease, but is not significantly expressed in human brain.
- Belongs to peptidase family A1.
|
| Cross-references |
|---|
| PROSITE | PDOC00128 |
| BRENDA | 3.4.23.45 |
| EC2PDB | 3.4.23.45 |
| ExplorEnz | 3.4.23.45 |
| PRIAM enzyme-specific profiles | 3.4.23.45 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.23.45 |
| IUBMB Enzyme Nomenclature | 3.4.23.45 |
| IntEnz | 3.4.23.45 |
| MEDLINE | Find literature relating to 3.4.23.45 |
| MetaCyc | 3.4.23.45 |
| UniProtKB/Swiss-Prot |
|
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