ENZYME entry: EC 3.4.23.45
Accepted Name |
Memapsin 1.
|
Alternative Name(s) |
ASP1. |
BACE2. |
Beta-secretase. |
Beta-site Alzheimer's amyloid precursor protein cleaving enzyme 2. |
Beta-site APP-cleaving enzyme 2. |
Down region aspartic protease. |
Membrane-associated aspartic protease 1. |
Reaction catalysed |
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein |
Comment(s) |
- Can cleave beta-amyloid precursor protein to form the amyloidogenic
beta-peptide that is implicated in the pathology of Alzheimer's
disease, but is not significantly expressed in human brain.
- Belongs to peptidase family A1.
|
Cross-references |
PROSITE | PDOC00128 |
BRENDA | 3.4.23.45 |
EC2PDB | 3.4.23.45 |
ExplorEnz | 3.4.23.45 |
PRIAM enzyme-specific profiles | 3.4.23.45 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.23.45 |
IUBMB Enzyme Nomenclature | 3.4.23.45 |
IntEnz | 3.4.23.45 |
MEDLINE | Find literature relating to 3.4.23.45 |
MetaCyc | 3.4.23.45 |
UniProtKB/Swiss-Prot |
|
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