ID   3.4.23.46
DE   memapsin 2.
AN   BACE1.
AN   beta-secretase.
AN   beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1.
AN   beta-site APP-cleaving enzyme 1.
AN   membrane-associated aspartic protease 2.
CA   Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-
CA   Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
CC   -!- Suggested to be the major 'beta-secretase' responsible for the
CC       cleavage of the beta-amyloid precursor protein to form the
CC       amyloidogenic beta-peptide that is implicated in the pathology of
CC       Alzheimer's disease.
CC   -!- Belongs to peptidase family A1.
DR   Q2HJ40, BACE1_BOVIN;  Q1KLR6, BACE1_CAVPO;  P56817, BACE1_HUMAN;
DR   P56818, BACE1_MOUSE;  P56819, BACE1_RAT  ;
//