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ENZYME entry: EC 3.4.24.1

Accepted Name
Atrolysin A.
Alternative Name(s)
Crotalus atrox alpha-proteinase.
Crotalus atrox metalloproteinase.
Hemorrhagic toxin a.
Reaction catalysed
Cleavage of 3-Asn-|-Gln-4, 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in insulin B chain. Removes C-terminal Leu from small peptides
Cofactor(s)
Zn(2+).
Comment(s)
  • A hemorrhagic endopeptidase of 68 kDa, one of six hemorrhagic toxins in the venom of the western diamondback rattlesnake.
  • The 60 kDa hemorrhagic toxin 1 of Crotalus ruber ruber shows identical specificity.
  • Belongs to peptidase family M12B.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.1
EC2PDB3.4.24.1
ExplorEnz3.4.24.1
PRIAM enzyme-specific profiles3.4.24.1
KEGG Ligand Database for Enzyme Nomenclature3.4.24.1
IUBMB Enzyme Nomenclature3.4.24.1
IntEnz3.4.24.1
MEDLINEFind literature relating to 3.4.24.1
MetaCyc3.4.24.1
Rhea expert-curated reactions3.4.24.1
UniProtKB/Swiss-Prot
Q92043, VM3AA_CROAT

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