A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.24.1
| Accepted Name |
|---|
| Atrolysin A.
|
| Alternative Name(s) |
|---|
| Crotalus atrox alpha-proteinase. |
| Crotalus atrox metalloproteinase. |
| Hemorrhagic toxin a. |
| Reaction catalysed |
|---|
| Cleavage of 3-Asn-|-Gln-4, 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in insulin B chain. Removes C-terminal Leu from small peptides |
| Cofactor(s) |
|---|
| Zn(2+).
|
| Comment(s) |
|---|
- A hemorrhagic endopeptidase of 68 kDa, one of six hemorrhagic toxins
in the venom of the western diamondback rattlesnake.
- The 60 kDa hemorrhagic toxin 1 of Crotalus ruber ruber shows
identical specificity.
- Belongs to peptidase family M12B.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.24.1 |
| EC2PDB | 3.4.24.1 |
| ExplorEnz | 3.4.24.1 |
| PRIAM enzyme-specific profiles | 3.4.24.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.1 |
| IUBMB Enzyme Nomenclature | 3.4.24.1 |
| IntEnz | 3.4.24.1 |
| MEDLINE | Find literature relating to 3.4.24.1 |
| MetaCyc | 3.4.24.1 |
| UniProtKB/Swiss-Prot |
|
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-