ID 3.4.24.11 DE neprilysin. AN endopeptidase-2. AN enkephalinase. AN kidney-brush-border neutral proteinase. AN membrane metalloendopeptidase. AN neutral endopeptidase. CA Preferential cleavage of polypeptides between hydrophobic residues, CA particularly with Phe or Tyr at P1'. CC -!- A membrane-bound glycoprotein widely distributed in animal tissues. CC -!- Inhibited by phosphoramidon and thiorphan. CC -!- Belongs to peptidase family M13. DR Q495T6, MMEL1_HUMAN; Q9JLI3, MMEL1_MOUSE; P0C1T0, MMEL1_RAT ; DR A0A0B4K692, NEP2_DROME ; Q9W5Y0, NEP3_DROME ; Q8T062, NEP4_DROME ; DR Q9W436, NEP_DROME ; P08473, NEP_HUMAN ; Q61391, NEP_MOUSE ; DR P19621, NEP_PIG ; Q5RE69, NEP_PONAB ; P08049, NEP_RABIT ; DR P07861, NEP_RAT ; //