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ENZYME entry: EC 3.4.24.14

Accepted Name
Procollagen N-endopeptidase.
Alternative Name(s)
Procollagen N-proteinase.
Reaction catalysed
Cleaves the N-propeptide of collagen chain alpha-1(I) at Pro-|-Gln and of alpha-1(II) and alpha-2(I) at Ala-|-Gln
Cofactor(s)
Zn(2+).
Comment(s)
  • Removes N-terminal propeptides of type I and II collagens prior to fibril assembly.
  • Does not cleave type III procollagen.
  • Belongs to peptidase family M12.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.14
EC2PDB3.4.24.14
ExplorEnz3.4.24.14
PRIAM enzyme-specific profiles3.4.24.14
KEGG Ligand Database for Enzyme Nomenclature3.4.24.14
IUBMB Enzyme Nomenclature3.4.24.14
IntEnz3.4.24.14
MEDLINEFind literature relating to 3.4.24.14
MetaCyc3.4.24.14
Rhea expert-curated reactions3.4.24.14
UniProtKB/Swiss-Prot
P79331, ATS2_BOVIN;  O95450, ATS2_HUMAN;  Q8C9W3, ATS2_MOUSE;  

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