ENZYME entry: EC 3.4.24.14
Accepted Name |
Procollagen N-endopeptidase.
|
Alternative Name(s) |
Procollagen N-proteinase. |
Reaction catalysed |
Cleaves the N-propeptide of collagen chain alpha-1(I) at Pro-|-Gln and of alpha-1(II) and alpha-2(I) at Ala-|-Gln |
Cofactor(s) |
Zn(2+).
|
Comment(s) |
- Removes N-terminal propeptides of type I and II collagens prior to
fibril assembly.
- Does not cleave type III procollagen.
- Belongs to peptidase family M12.
|
Cross-references |
PROSITE | PDOC00129 |
BRENDA | 3.4.24.14 |
EC2PDB | 3.4.24.14 |
ExplorEnz | 3.4.24.14 |
PRIAM enzyme-specific profiles | 3.4.24.14 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.14 |
IUBMB Enzyme Nomenclature | 3.4.24.14 |
IntEnz | 3.4.24.14 |
MEDLINE | Find literature relating to 3.4.24.14 |
MetaCyc | 3.4.24.14 |
Rhea expert-curated reactions | 3.4.24.14 |
UniProtKB/Swiss-Prot |
|
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