ENZYME entry: EC 3.4.24.23
Accepted Name |
Matrilysin.
|
Alternative Name(s) |
Matrin. |
Matrix metalloproteinase 7. |
PUMP-1. |
Putative (or punctuated) metalloproteinase-1. |
Uterine metalloendopeptidase. |
Reaction catalysed |
Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I) |
Cofactor(s) |
Ca(2+); Zn(2+).
|
Comment(s) |
- Similar in specificity to stromelysin, but more active on azocoll.
- Belongs to peptidase family M10B.
|
Cross-references |
PROSITE | PDOC00129 |
BRENDA | 3.4.24.23 |
EC2PDB | 3.4.24.23 |
ExplorEnz | 3.4.24.23 |
PRIAM enzyme-specific profiles | 3.4.24.23 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.23 |
IUBMB Enzyme Nomenclature | 3.4.24.23 |
IntEnz | 3.4.24.23 |
MEDLINE | Find literature relating to 3.4.24.23 |
MetaCyc | 3.4.24.23 |
Rhea expert-curated reactions | 3.4.24.23 |
UniProtKB/Swiss-Prot |
|
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