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ENZYME entry: EC 3.4.24.23

Accepted Name
Matrilysin.
Alternative Name(s)
Matrin.
Matrix metalloproteinase 7.
PUMP-1.
Putative (or punctuated) metalloproteinase-1.
Uterine metalloendopeptidase.
Reaction catalysed
Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)
Cofactor(s)
Ca(2+); Zn(2+).
Comment(s)
  • Similar in specificity to stromelysin, but more active on azocoll.
  • Belongs to peptidase family M10B.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.23
EC2PDB3.4.24.23
ExplorEnz3.4.24.23
PRIAM enzyme-specific profiles3.4.24.23
KEGG Ligand Database for Enzyme Nomenclature3.4.24.23
IUBMB Enzyme Nomenclature3.4.24.23
IntEnz3.4.24.23
MEDLINEFind literature relating to 3.4.24.23
MetaCyc3.4.24.23
Rhea expert-curated reactions3.4.24.23
UniProtKB/Swiss-Prot
P55032, MMP7_FELCA;  P09237, MMP7_HUMAN;  Q10738, MMP7_MOUSE;  
P50280, MMP7_RAT;  

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