A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.24.23
| Accepted Name |
|---|
| Matrilysin.
|
| Alternative Name(s) |
|---|
| Matrin. |
| Matrix metalloproteinase 7. |
| PUMP-1. |
| Putative (or punctuated) metalloproteinase-1. |
| Uterine metalloendopeptidase. |
| Reaction catalysed |
|---|
| Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I) |
| Cofactor(s) |
|---|
| Ca(2+); Zn(2+).
|
| Comment(s) |
|---|
- Similar in specificity to stromelysin, but more active on azocoll.
- Belongs to peptidase family M10B.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.24.23 |
| EC2PDB | 3.4.24.23 |
| ExplorEnz | 3.4.24.23 |
| PRIAM enzyme-specific profiles | 3.4.24.23 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.23 |
| IUBMB Enzyme Nomenclature | 3.4.24.23 |
| IntEnz | 3.4.24.23 |
| MEDLINE | Find literature relating to 3.4.24.23 |
| MetaCyc | 3.4.24.23 |
| UniProtKB/Swiss-Prot |
|
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