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ENZYME entry: EC 3.4.24.27

Accepted Name
Thermolysin.
Alternative Name(s)
Bacillus thermoproteolyticus neutral proteinase.
Reaction catalysed
Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe
Cofactor(s)
Ca(2+); Zn(2+).
Comment(s)
  • A thermostable extracellular metalloendopeptidase containing four calcium ions.
  • Enzymes that may be species variants of thermolysin are reported from Micrococcus caseolyticus and Aspergillus oryzae.
  • Closely related but distinct enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin and mycolysin.
  • Belongs to peptidase family M4.
  • Formerly EC 3.4.24.4.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.27
EC2PDB3.4.24.27
ExplorEnz3.4.24.27
PRIAM enzyme-specific profiles3.4.24.27
KEGG Ligand Database for Enzyme Nomenclature3.4.24.27
IUBMB Enzyme Nomenclature3.4.24.27
IntEnz3.4.24.27
MEDLINEFind literature relating to 3.4.24.27
MetaCyc3.4.24.27
UniProtKB/Swiss-Prot
Q43880, THER_ALIAC;  Q59193, THER_BACCL;  Q59223, THER_BACSO;  
P00800, THER_BACTH;  P43133, THER_GEOSE;  

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