ENZYME entry: EC 3.4.24.36
Accepted Name |
Leishmanolysin.
|
Alternative Name(s) |
Glycoprotein gp63. |
Promastigote surface endopeptidase. |
Reaction catalysed |
Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys- |
Cofactor(s) |
Ca(2+); Zn(2+).
|
Comment(s) |
- A membrane-bound glycoprotein found on the promastigote of various
species of Leishmania protozoans.
- Contains consensus sequence for a zinc binding site; Z-Tyr-Leu-NHOH
is a strong inhibitor.
- The enzyme can activate its proenzyme by cleavage of the 100-
Val-|-Val-101 bond.
- An acidic pH optimum is found with certain protein substrates.
- Belongs to peptidase family M8.
|
Cross-references |
PROSITE | PDOC00129 |
BRENDA | 3.4.24.36 |
EC2PDB | 3.4.24.36 |
ExplorEnz | 3.4.24.36 |
PRIAM enzyme-specific profiles | 3.4.24.36 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.36 |
IUBMB Enzyme Nomenclature | 3.4.24.36 |
IntEnz | 3.4.24.36 |
MEDLINE | Find literature relating to 3.4.24.36 |
MetaCyc | 3.4.24.36 |
UniProtKB/Swiss-Prot |
|
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