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ENZYME entry: EC 3.4.24.36

Accepted Name
Leishmanolysin.
Alternative Name(s)
Glycoprotein gp63.
Promastigote surface endopeptidase.
Reaction catalysed
Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-
Cofactor(s)
Ca(2+); Zn(2+).
Comment(s)
  • A membrane-bound glycoprotein found on the promastigote of various species of Leishmania protozoans.
  • Contains consensus sequence for a zinc binding site; Z-Tyr-Leu-NHOH is a strong inhibitor.
  • The enzyme can activate its proenzyme by cleavage of the 100- Val-|-Val-101 bond.
  • An acidic pH optimum is found with certain protein substrates.
  • Belongs to peptidase family M8.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.36
EC2PDB3.4.24.36
ExplorEnz3.4.24.36
PRIAM enzyme-specific profiles3.4.24.36
KEGG Ligand Database for Enzyme Nomenclature3.4.24.36
IUBMB Enzyme Nomenclature3.4.24.36
IntEnz3.4.24.36
MEDLINEFind literature relating to 3.4.24.36
MetaCyc3.4.24.36
Rhea expert-curated reactions3.4.24.36
UniProtKB/Swiss-Prot
Q06031, GP63_CRIFA;  Q27673, GP63_LEIAM;  P15706, GP63_LEICH;  
P23223, GP63_LEIDO;  Q00689, GP63_LEIGU;  P08148, GP63_LEIMA;  
P43150, GP63_LEIME;  Q8MNZ1, GP63_LEITR;  

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