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ENZYME

ENZYME entry: EC 3.4.24.39

PURL: https://purl.expasy.org/enzyme/EC/3.4.24.39
Accepted Name
deuterolysin
Alternative Name(s)
acid metalloproteinase
microbial neutral proteinase II
Penicillium roqueforti protease II
Reaction catalysed
Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain
Comment(s)
  • Proteolytic activity found in Penicillium roqueforti, P.caseicolum, Aspergillus sojae and A.oryzae.
  • Optimum pH of 5 for digesting various proteins.
  • Strong action on protamine and histones.
  • Insensitive to phosphoramidon.
  • A distinct A.sojae endopeptidase is larger and has neutral pH optimum.
  • Belongs to peptidase family M35.
  • Formerly EC 3.4.24.4.
Cross-references
BRENDA3.4.24.39
EC2PDB3.4.24.39
ExplorEnz3.4.24.39
KEGG Ligand Database for Enzyme Nomenclature3.4.24.39
IUBMB Enzyme Nomenclature3.4.24.39
MEDLINEFind literature relating to 3.4.24.39
MetaCyc3.4.24.39
Rhea expert-curated reactions3.4.24.39
UniProtKB/Swiss-Prot
P46073, MEP20_ASPFLQ09016, MEP20_ASPFMC5PE62, MEP2_COCP7
C5P507, MEP3_COCP7C5PIJ9, MEP4_COCP7C5NZY5, MEP5_COCP7
C5PE18, MEP6_COCP7C5P3T4, MEP7_COCP7C5NZL6, MEP8_COCP7
C5G8P3, NPIIA_AJEDRE4UUX3, NPIIA_ARTGPC5FR79, NPIIA_ARTOC
A1CIU4, NPIIA_ASPCLB0YEV0, NPIIA_ASPFCB8NJB2, NPIIA_ASPFN
Q4WQR6, NPIIA_ASPFUQ2UP30, NPIIA_ASPORQ0CMZ3, NPIIA_ASPTN
C5JKQ0, NPIIA_BLAGSA6SBW7, NPIIA_BOTFBE3QWD3, NPIIA_COLGM
Q5AUR8, NPIIA_EMENIA1DA48, NPIIA_NEOFIC1G1N6, NPIIA_PARBD
C0S3U8, NPIIA_PARBPQ0UCJ2, NPIIA_PHANOQ2KH28, NPIIA_PYRO7
A7F811, NPIIA_SCLS1C0IPP1, NPIIA_TRIRUC4JLQ3, NPIIA_UNCRE
D4ANL2, NPIIB_ARTBCE5R1Z3, NPIIB_ARTGPC5FCA7, NPIIB_ARTOC
B0Y4X9, NPIIB_ASPFCB8NWE1, NPIIB_ASPFNC5JHY1, NPIIB_BLAGS
Q5B7T7, NPIIB_EMENIA1CVX6, NPIIB_NEOFIQ0V1D7, NPIIB_PHANO
C0IPP2, NPIIB_TRIRUD4DE03, NPIIB_TRIVHC4JK49, NPIIB_UNCRE
D4AM79, NPIIC_ARTBCE4UR63, NPIIC_ARTGPC5FPC2, NPIIC_ARTOC
Q4WA45, NPIIC_ASPFUD4DGR5, NPIIC_TRIVHC4JH04, NPIIC_UNCRE
D4B639, NPIID_ARTBCE4US45, NPIID_ARTGPC5FWQ2, NPIID_ARTOC
D4D616, NPIID_TRIVHD4AXC1, NPIIE_ARTBCC5FIT1, NPIIE_ARTOC
D4AJ87, NPIIF_ARTBCE4UYQ9, NPIIF_ARTGPD4D7X4, NPIIF_TRIVH
P46076, NPII_ASPORP47189, PLNC_PENCI

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