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ENZYME

ENZYME entry: EC 3.4.24.40

PURL: https://purl.expasy.org/enzyme/EC/3.4.24.40
Accepted Name
serralysin
Alternative Name(s)
Escherichia freundii proteinase
Pseudomonas aeruginosa alkaline protease
Serratia marcescens extracellular proteinase
Reaction catalysed
Preferential cleavage of bonds with hydrophobic residues in P1'
Comment(s)
  • An extracellular endopeptidase from Pseudomonas aeruginosa, Escherichia freundii, Serratia marcescens and Erwinia chrysanthemi.
  • There is broad specificity in cleavage of the insulin B chain, with some species variations.
  • The pH optimum for digesting various proteins is about 9-10.
  • Belongs to peptidase family M10A.
  • Formerly EC 3.4.24.4.
Cross-references
BRENDA3.4.24.40
EC2PDB3.4.24.40
ExplorEnz3.4.24.40
KEGG Ligand Database for Enzyme Nomenclature3.4.24.40
IUBMB Enzyme Nomenclature3.4.24.40
MEDLINEFind literature relating to 3.4.24.40
MetaCyc3.4.24.40
Rhea expert-curated reactions3.4.24.40
UniProtKB/Swiss-Prot
Q03023, APRA_PSEAEQ84F70, PRTA1_PHOLUQ07295, PRTA_DICCH
P82115, PRTA_PHOAZQ7N8R3, PRTA_PHOLLP16316, PRTB_DICCH
P16317, PRTC_DICCHQ07162, PRTG_DICCHP19144, PRTX_DICCH
P23694, PRZN_SERMAP07268, PRZN_SERMEQ11137, ZAPA_PROMI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.24.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-