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ENZYME entry: EC 3.4.24.41

Accepted Name
Atrolysin B.
Alternative Name(s)
Crotalus atrox metalloendopeptidase b.
Hemorrhagic toxin b.
Ht-b.
Reaction catalysed
Cleavage of 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 23-Gly-|-Phe-24 of insulin B chain. Identical to the cleavage of insulin B chain by atrolysin C. Also cleaves Xaa-|-Ser bonds in glucagon
Cofactor(s)
Zn(2+).
Comment(s)
  • From the venom of the western diamondback rattlesnake (Crotalus atrox).
  • Belongs to peptidase family M12B.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.41
EC2PDB3.4.24.41
ExplorEnz3.4.24.41
PRIAM enzyme-specific profiles3.4.24.41
KEGG Ligand Database for Enzyme Nomenclature3.4.24.41
IUBMB Enzyme Nomenclature3.4.24.41
IntEnz3.4.24.41
MEDLINEFind literature relating to 3.4.24.41
MetaCyc3.4.24.41
UniProtKB/Swiss-Prot
Q90391, VM1AB_CROAT

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