ENZYME entry: EC 3.4.24.42
Accepted Name |
atrolysin C.
|
Alternative Name(s) |
Crotalus atrox metalloendopeptidase c. |
hemorrhagic toxin c. |
Ht-c. |
Reaction catalysed |
Cleavage of 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 23-Gly-|-Phe-24 of insulin B chain. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1 |
Comment(s) |
- Hemorrhagic endopeptidase from the venom of the western diamondback
rattlesnake (Crotalus atrox).
- Exist as two forms, c and d.
- Digests type IV collagen.
- Phosphoramidon inhibits in the 0.1 mM range.
- Hemorrhagic toxin-2 of C.ruber ruber has the same molecular weight
and specificity.
- Belongs to peptidase family M12B.
|
Cross-references |
BRENDA | 3.4.24.42 |
EC2PDB | 3.4.24.42 |
ExplorEnz | 3.4.24.42 |
PRIAM enzyme-specific profiles | 3.4.24.42 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.42 |
IUBMB Enzyme Nomenclature | 3.4.24.42 |
IntEnz | 3.4.24.42 |
MEDLINE | Find literature relating to 3.4.24.42 |
MetaCyc | 3.4.24.42 |
Rhea expert-curated reactions | 3.4.24.42 |
UniProtKB/Swiss-Prot |
|
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