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ENZYME entry: EC 3.4.24.42

Accepted Name
Atrolysin C.
Alternative Name(s)
Crotalus atrox metalloendopeptidase c.
Hemorrhagic toxin c.
Ht-c.
Reaction catalysed
Cleavage of 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 23-Gly-|-Phe-24 of insulin B chain. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1
Cofactor(s)
Zn(2+).
Comment(s)
  • Hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox).
  • Exist as two forms, c and d.
  • Digests type IV collagen.
  • Phosphoramidon inhibits in the 0.1 mM range.
  • Hemorrhagic toxin-2 of C.ruber ruber has the same molecular weight and specificity.
  • Belongs to peptidase family M12B.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.42
EC2PDB3.4.24.42
ExplorEnz3.4.24.42
PRIAM enzyme-specific profiles3.4.24.42
KEGG Ligand Database for Enzyme Nomenclature3.4.24.42
IUBMB Enzyme Nomenclature3.4.24.42
IntEnz3.4.24.42
MEDLINEFind literature relating to 3.4.24.42
MetaCyc3.4.24.42
Rhea expert-curated reactions3.4.24.42
UniProtKB/Swiss-Prot
Q90392, VM1AC_CROAT;  P15167, VM1AD_CROAT;  

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