ENZYME entry: EC 3.4.24.44
Accepted Name |
Atrolysin E.
|
Alternative Name(s) |
Crotalus atrox metalloendopeptidase e. |
Hemorrhagic toxin e. |
Reaction catalysed |
Cleavage of 3-Asn-|-Gln-4, 9-Ser-|-His-10 and 14-Ala-|-Leu-15 bonds in insulin B chain and 14-Tyr-|-Gln-15 and 8-Thr-|-Ser-9 in A chain. Cleaves type IV collagen at 73-Ala-|-Gln-74 in alpha-1-(IV) and at 7-Gly-|-Leu-8 in alpha-2-(IV) |
Cofactor(s) |
Zn(2+).
|
Comment(s) |
- Hemorrhagic endopeptidase from the venom of the western diamondback
rattlesnake (Crotalus atrox).
- Digests basement membrane components, including the triple helix of
type IV collagen.
- Such action is believed to contribute to the hemorrhagic property by
weakening capillary walls.
- Belongs to peptidase family M12B.
|
Cross-references |
PROSITE | PDOC00129 |
BRENDA | 3.4.24.44 |
EC2PDB | 3.4.24.44 |
ExplorEnz | 3.4.24.44 |
PRIAM enzyme-specific profiles | 3.4.24.44 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.44 |
IUBMB Enzyme Nomenclature | 3.4.24.44 |
IntEnz | 3.4.24.44 |
MEDLINE | Find literature relating to 3.4.24.44 |
MetaCyc | 3.4.24.44 |
Rhea expert-curated reactions | 3.4.24.44 |
UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.24.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-