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ENZYME entry: EC 3.4.24.44

Accepted Name
Atrolysin E.
Alternative Name(s)
Crotalus atrox metalloendopeptidase e.
Hemorrhagic toxin e.
Reaction catalysed
Cleavage of 3-Asn-|-Gln-4, 9-Ser-|-His-10 and 14-Ala-|-Leu-15 bonds in insulin B chain and 14-Tyr-|-Gln-15 and 8-Thr-|-Ser-9 in A chain. Cleaves type IV collagen at 73-Ala-|-Gln-74 in alpha-1-(IV) and at 7-Gly-|-Leu-8 in alpha-2-(IV)
Cofactor(s)
Zn(2+).
Comment(s)
  • Hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox).
  • Digests basement membrane components, including the triple helix of type IV collagen.
  • Such action is believed to contribute to the hemorrhagic property by weakening capillary walls.
  • Belongs to peptidase family M12B.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.44
EC2PDB3.4.24.44
ExplorEnz3.4.24.44
PRIAM enzyme-specific profiles3.4.24.44
KEGG Ligand Database for Enzyme Nomenclature3.4.24.44
IUBMB Enzyme Nomenclature3.4.24.44
IntEnz3.4.24.44
MEDLINEFind literature relating to 3.4.24.44
MetaCyc3.4.24.44
Rhea expert-curated reactions3.4.24.44
UniProtKB/Swiss-Prot
P34182, VM2AE_CROAT

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