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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.24.45

Accepted Name
Atrolysin F.
Alternative Name(s)
Crotalus atrox metalloendopeptidase f.
Hemorrhagic toxin f.
Reaction catalysed
Cleavage of 2-Val-|-Asn-3, 4-Gln-|-His-5, 6-Leu-|-Cys-7, 10-His-|-Leu-11, 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 bonds in insulin B chain
Cofactor(s)
Zn(2+).
Comment(s)
  • Hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox).
  • Digests the gamma chain of fibrinogen.
  • Belongs to peptidase family M12B.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.45
EC2PDB3.4.24.45
ExplorEnz3.4.24.45
PRIAM enzyme-specific profiles3.4.24.45
KEGG Ligand Database for Enzyme Nomenclature3.4.24.45
IUBMB Enzyme Nomenclature3.4.24.45
IntEnz3.4.24.45
MEDLINEFind literature relating to 3.4.24.45
MetaCyc3.4.24.45

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.24.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-