ENZYME entry: EC 3.4.24.47
| Accepted Name |
|---|
| Horrilysin.
|
| Alternative Name(s) |
|---|
| Crotalus horridus metalloendopeptidase. |
| Hemorrhagic proteinase IV. |
| Reaction catalysed |
|---|
| Cleavage of only the single bond 14-Ala-|-Leu-15 in the insulin B chain, 12-Ser-|-Leu-13 in the A chain, and Ile-|-Gly, Pro-|-Ala, and Ser-|-Trp in mellitin |
| Cofactor(s) |
|---|
| Zn(2+).
|
| Comment(s) |
|---|
- Cleaves basement membrane, hide powder and fibrinogen.
- Hemorrhagic endopeptidase from the venom of the timber rattlesnake
(Crotalus horridus horridus).
- Belongs to peptidase family M12B.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.24.47 |
| EC2PDB | 3.4.24.47 |
| ExplorEnz | 3.4.24.47 |
| PRIAM enzyme-specific profiles | 3.4.24.47 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.47 |
| IUBMB Enzyme Nomenclature | 3.4.24.47 |
| IntEnz | 3.4.24.47 |
| MEDLINE | Find literature relating to 3.4.24.47 |
| MetaCyc | 3.4.24.47 |
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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