ENZYME entry: EC 3.4.24.47
Accepted Name |
Horrilysin.
|
Alternative Name(s) |
Crotalus horridus metalloendopeptidase. |
Hemorrhagic proteinase IV. |
Reaction catalysed |
Cleavage of only the single bond 14-Ala-|-Leu-15 in the insulin B chain, 12-Ser-|-Leu-13 in the A chain, and Ile-|-Gly, Pro-|-Ala, and Ser-|-Trp in mellitin |
Cofactor(s) |
Zn(2+).
|
Comment(s) |
- Cleaves basement membrane, hide powder and fibrinogen.
- Hemorrhagic endopeptidase from the venom of the timber rattlesnake
(Crotalus horridus horridus).
- Belongs to peptidase family M12B.
|
Cross-references |
PROSITE | PDOC00129 |
BRENDA | 3.4.24.47 |
EC2PDB | 3.4.24.47 |
ExplorEnz | 3.4.24.47 |
PRIAM enzyme-specific profiles | 3.4.24.47 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.47 |
IUBMB Enzyme Nomenclature | 3.4.24.47 |
IntEnz | 3.4.24.47 |
MEDLINE | Find literature relating to 3.4.24.47 |
MetaCyc | 3.4.24.47 |
Rhea expert-curated reactions | 3.4.24.47 |
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UniProtKB/Swiss-Prot entries corresponding to 3.4.24.-
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