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ENZYME entry: EC 3.4.24.48

Accepted Name
Ruberlysin.
Alternative Name(s)
Crotalus ruber metalloendopeptidase II.
Hemorrhagic metalloproteinase HT-2.
Hemorrhagic toxin II.
Reaction catalysed
Cleavage of 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 23-Gly-|-Phe-24 bonds of the B chain of insulin, His-|-Pro, Pro-|-Phe, and Trp-|-Ser of angiotensin I, and Gly-|-Phe of Met enkephalin
Cofactor(s)
Zn(2+).
Comment(s)
  • Hemorrhagic endopeptidase from the venom of the red rattlesnake (Crotalus ruber ruber).
  • Cleaves fibrinogen.
  • Belongs to peptidase family M12B.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.48
EC2PDB3.4.24.48
ExplorEnz3.4.24.48
PRIAM enzyme-specific profiles3.4.24.48
KEGG Ligand Database for Enzyme Nomenclature3.4.24.48
IUBMB Enzyme Nomenclature3.4.24.48
IntEnz3.4.24.48
MEDLINEFind literature relating to 3.4.24.48
MetaCyc3.4.24.48
Rhea expert-curated reactions3.4.24.48
UniProtKB/Swiss-Prot
P20897, VM1H2_CRORU

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