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ENZYME entry: EC 3.4.24.55

Accepted Name
Pitrilysin.
Alternative Name(s)
Protease III.
Protease Pi.
Reaction catalysed
Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|-Tyr-26 bonds of oxidized insulin B chain. Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon
Cofactor(s)
Zn(2+).
Comment(s)
  • From the periplasmic space of Escherichia coli.
  • Inhibited by EDTA and 1,10-phenanthroline; not thiol dependent.
  • Belongs to peptidase family M16.
  • Formerly EC 3.4.99.44.
Cross-references
PROSITEPDOC00130
BRENDA3.4.24.55
EC2PDB3.4.24.55
ExplorEnz3.4.24.55
PRIAM enzyme-specific profiles3.4.24.55
KEGG Ligand Database for Enzyme Nomenclature3.4.24.55
IUBMB Enzyme Nomenclature3.4.24.55
IntEnz3.4.24.55
MEDLINEFind literature relating to 3.4.24.55
MetaCyc3.4.24.55
Rhea expert-curated reactions3.4.24.55
UniProtKB/Swiss-Prot
Q8X6M8, PTRA_ECO57;  Q8CVS2, PTRA_ECOL6;  P05458, PTRA_ECOLI;  
Q8Z418, PTRA_SALTI;  Q8ZMB5, PTRA_SALTY;  Q83QC3, PTRA_SHIFL;  

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