ENZYME entry: EC 3.4.24.55
| Accepted Name |
|---|
| pitrilysin.
|
| Alternative Name(s) |
|---|
| protease III. |
| protease Pi. |
| Reaction catalysed |
|---|
| Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|-Tyr-26 bonds of oxidized insulin B chain. Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon |
| Comment(s) |
|---|
- From the periplasmic space of Escherichia coli.
- Inhibited by EDTA and 1,10-phenanthroline; not thiol dependent.
- Belongs to peptidase family M16.
- Formerly EC 3.4.99.44.
|
| Cross-references |
|---|
| BRENDA | 3.4.24.55 |
| EC2PDB | 3.4.24.55 |
| ExplorEnz | 3.4.24.55 |
| PRIAM enzyme-specific profiles | 3.4.24.55 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.55 |
| IUBMB Enzyme Nomenclature | 3.4.24.55 |
| IntEnz | 3.4.24.55 |
| MEDLINE | Find literature relating to 3.4.24.55 |
| MetaCyc | 3.4.24.55 |
| Rhea expert-curated reactions | 3.4.24.55 |
| UniProtKB/Swiss-Prot |
|
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