ENZYME entry: EC 3.4.24.55
Accepted Name |
pitrilysin.
|
Alternative Name(s) |
protease III. |
protease Pi. |
Reaction catalysed |
Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|-Tyr-26 bonds of oxidized insulin B chain. Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon |
Comment(s) |
- From the periplasmic space of Escherichia coli.
- Inhibited by EDTA and 1,10-phenanthroline; not thiol dependent.
- Belongs to peptidase family M16.
- Formerly EC 3.4.99.44.
|
Cross-references |
BRENDA | 3.4.24.55 |
EC2PDB | 3.4.24.55 |
ExplorEnz | 3.4.24.55 |
PRIAM enzyme-specific profiles | 3.4.24.55 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.55 |
IUBMB Enzyme Nomenclature | 3.4.24.55 |
IntEnz | 3.4.24.55 |
MEDLINE | Find literature relating to 3.4.24.55 |
MetaCyc | 3.4.24.55 |
Rhea expert-curated reactions | 3.4.24.55 |
UniProtKB/Swiss-Prot |
|
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