ID 3.4.24.56 DE Insulysin. AN Insulin protease. AN Insulin-degrading enzyme. AN Insulinase. CA Degradation of insulin, glucagon and other polypeptides. No action on CA proteins. CF Zn(2+). CC -!- Cytosolic enzyme, known from mammals and Drosophila melanogaster. CC -!- Inhibited by bacitracin, chelating agents EDTA and 1,10- CC phenanthroline, and by thiol-blocking reagents such as CC N-ethylmaleimide, but not by phosphoramidon. CC -!- Belongs to peptidase family M16. CC -!- Formerly EC 3.4.22.11, EC 3.4.99.10 and EC 3.4.99.45. PR PROSITE; PDOC00130; DR Q24K02, IDE_BOVIN ; P22817, IDE_DROME ; P14735, IDE_HUMAN ; DR Q9JHR7, IDE_MOUSE ; P35559, IDE_RAT ; //