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ENZYME entry: EC 3.4.24.61

Accepted Name
Nardilysin.
Alternative Name(s)
N-arginine dibasic convertase.
NRD convertase.
Reaction catalysed
Hydrolysis of polypeptides, preferably at -Xaa-|-Arg-Lys-, and less commonly at -Arg-|-Arg-Xaa-, in which Xaa is not Arg or Lys
Cofactor(s)
Zn(2+).
Comment(s)
  • Unusually for a metallopeptidase, inhibited by bestatin, amastin and ethylmaleimide.
  • Belongs to peptidase family M16.
Cross-references
PROSITEPDOC00130
BRENDA3.4.24.61
EC2PDB3.4.24.61
ExplorEnz3.4.24.61
PRIAM enzyme-specific profiles3.4.24.61
KEGG Ligand Database for Enzyme Nomenclature3.4.24.61
IUBMB Enzyme Nomenclature3.4.24.61
IntEnz3.4.24.61
MEDLINEFind literature relating to 3.4.24.61
MetaCyc3.4.24.61
Rhea expert-curated reactions3.4.24.61
UniProtKB/Swiss-Prot
F4HNU6, NRDC_ARATH;  O43847, NRDC_HUMAN;  Q8BHG1, NRDC_MOUSE;  
Q5R4H6, NRDC_PONAB;  P47245, NRDC_RAT;  

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