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ENZYME entry: EC 3.4.24.63

Accepted Name
Meprin B.
Reaction catalysed
Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of 5-His-|-Leu-6, 6-Leu-|-Cys-7, 14-Ala-|-Leu-15 and 19-Cys-|-Gly-20 bonds in insulin B chain
Cofactor(s)
Zn(2+).
Comment(s)
  • Inhibited by EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan.
  • Belongs to peptidase family M12A.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.63
EC2PDB3.4.24.63
ExplorEnz3.4.24.63
PRIAM enzyme-specific profiles3.4.24.63
KEGG Ligand Database for Enzyme Nomenclature3.4.24.63
IUBMB Enzyme Nomenclature3.4.24.63
IntEnz3.4.24.63
MEDLINEFind literature relating to 3.4.24.63
MetaCyc3.4.24.63
UniProtKB/Swiss-Prot
Q16820, MEP1B_HUMAN;  Q61847, MEP1B_MOUSE;  P28826, MEP1B_RAT;  

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