A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.24.64

Accepted Name
Mitochondrial processing peptidase.
Alternative Name(s)
Processing enhancing peptidase.
Reaction catalysed
Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2
Cofactor(s)
Zn(2+).
Comment(s)
  • Known from the mitochondrial matrix of fungi and mammals.
  • Belongs to peptidase family M16.
  • Formerly EC 3.4.99.41.
Cross-references
PROSITEPDOC00130
BRENDA3.4.24.64
EC2PDB3.4.24.64
ExplorEnz3.4.24.64
PRIAM enzyme-specific profiles3.4.24.64
KEGG Ligand Database for Enzyme Nomenclature3.4.24.64
IUBMB Enzyme Nomenclature3.4.24.64
IntEnz3.4.24.64
MEDLINEFind literature relating to 3.4.24.64
MetaCyc3.4.24.64
UniProtKB/Swiss-Prot
Q9ZU25, MPPA1_ARATH;  O04308, MPPA2_ARATH;  P97997, MPPA_BLAEM;  
P23955, MPPA_NEUCR;  O94745, MPPA_SCHPO;  P29677, MPPA_SOLTU;  
P11914, MPPA_YEAST;  Q42290, MPPB_ARATH;  Q00302, MPPB_BLAEM;  
Q3SZ71, MPPB_BOVIN;  Q4W6B5, MPPB_DICDI;  O75439, MPPB_HUMAN;  
Q9Y8B5, MPPB_LENED;  Q9CXT8, MPPB_MOUSE;  P11913, MPPB_NEUCR;  
Q5REK3, MPPB_PONAB;  Q03346, MPPB_RAT;  Q9P7X1, MPPB_SCHPO;  
P10507, MPPB_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.24.-
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