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ENZYME entry: EC 3.4.24.65

Accepted Name
Macrophage elastase.
Alternative Name(s)
Matrix metalloproteinase 12.
Metalloelastase.
Reaction catalysed
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin
Cofactor(s)
Ca(2+); Zn(2+).
Comment(s)
Belongs to peptidase family M10B.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.65
EC2PDB3.4.24.65
ExplorEnz3.4.24.65
PRIAM enzyme-specific profiles3.4.24.65
KEGG Ligand Database for Enzyme Nomenclature3.4.24.65
IUBMB Enzyme Nomenclature3.4.24.65
IntEnz3.4.24.65
MEDLINEFind literature relating to 3.4.24.65
MetaCyc3.4.24.65
UniProtKB/Swiss-Prot
P39900, MMP12_HUMAN;  P34960, MMP12_MOUSE;  P79227, MMP12_RABIT;  
Q63341, MMP12_RAT;  

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