ID   3.4.24.7
DE   interstitial collagenase.
AN   matrix metalloproteinase 1.
AN   vertebrate collagenase.
CA   Cleavage of the triple helix of collagen at about three-quarters of the
CA   length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the
CA   alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at
CA   bonds where P1' is a hydrophobic residue.
CC   -!- The enzyme takes its name from substrates of the interstitial
CC       collagen group - types I, II and III, all of which are cleaved in the
CC       helical domain.
CC   -!- alpha-macroglobulins are cleaved much more rapidly.
CC   -!- The enzyme is widely distributed in vertebrate animals.
CC   -!- Belongs to peptidase family M10B.
DR   P34156, COG4_CHIOP ;  Q9EPL5, MMP1A_MOUSE;  Q9EPL6, MMP1B_MOUSE;
DR   Q11133, MMP1_AQUCT ;  P28053, MMP1_BOVIN ;  Q9XSZ5, MMP1_HORSE ;
DR   P03956, MMP1_HUMAN ;  P21692, MMP1_PIG   ;  P13943, MMP1_RABIT ;
DR   P81563, MMP1_RAT   ;
//