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ENZYME entry: EC 3.4.24.71

Accepted Name
Endothelin-converting enzyme 1.
Alternative Name(s)
ECE-1.
Reaction catalysed
Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1
Cofactor(s)
Zn(2+).
Comment(s)
  • Phosphoramidon-sensitive.
  • Belongs to peptidase family M13.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.71
EC2PDB3.4.24.71
ExplorEnz3.4.24.71
PRIAM enzyme-specific profiles3.4.24.71
KEGG Ligand Database for Enzyme Nomenclature3.4.24.71
IUBMB Enzyme Nomenclature3.4.24.71
IntEnz3.4.24.71
MEDLINEFind literature relating to 3.4.24.71
MetaCyc3.4.24.71
Rhea expert-curated reactions3.4.24.71
UniProtKB/Swiss-Prot
P42891, ECE1_BOVIN;  P97739, ECE1_CAVPO;  P42892, ECE1_HUMAN;  
Q4PZA2, ECE1_MOUSE;  P42893, ECE1_RAT;  F1N476, ECE2_BOVIN;  
P0DPD6, ECE2_HUMAN;  B2RQR8, ECE2_MOUSE;  P0DPE2, EFCE2_BOVIN;  
P0DPD8, EFCE2_HUMAN;  P0DPD9, EFCE2_MOUSE;  

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