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ENZYME

ENZYME entry: EC 3.4.24.74

PURL: https://purl.expasy.org/enzyme/EC/3.4.24.74
Accepted Name
fragilysin
Alternative Name(s)
Bacteroides fragilis enterotoxin
Reaction catalysed
Broad proteolytic specificity, bonds hydrolyzed includes -Gly-|-Leu-, -Met-|-Leu-, -Phe-|-Leu-, -Cys-|-Leu-, -Leu-|-Gly-
Comment(s)
  • Thought to be a cause of diarrhea.
  • Hydrolyzes extracellular matrix proteins, and disrupts tight junctions of intstinal cells.
  • Also degrades intracellular, cytoskeletal proteins actin, myosin and others.
  • Belongs to peptidase family M10.
Cross-references
BRENDA3.4.24.74
EC2PDB3.4.24.74
ExplorEnz3.4.24.74
KEGG Ligand Database for Enzyme Nomenclature3.4.24.74
IUBMB Enzyme Nomenclature3.4.24.74
MEDLINEFind literature relating to 3.4.24.74
MetaCyc3.4.24.74
Rhea expert-curated reactions3.4.24.74
UniProtKB/Swiss-Prot
P54355, ENTM_BACFG

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