ID 3.4.24.79 DE pappalysin-1. AN insulin-like growth factor binding protein-4 protease. AN pregnancy-associated plasma protein-A. CA Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor CA binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5. CC -!- Circulates in human pregnancy mainly as a complex with the proform of CC eosinophil major basic protein, which acts as an inhibitor of the CC peptidase. CC -!- The rate of hydrolysis of IGFBP-4 is increased about 20-fold by the CC presence of insulin-like growth factor (IGF), whereas that of IGFBP-5 CC is decreased about two-fold. CC -!- Belongs to peptidase family M43. DR Q13219, PAPP1_HUMAN; Q8R4K8, PAPP1_MOUSE; //