ENZYME entry: EC 3.4.24.80
Accepted Name |
Membrane-type matrix metalloproteinase-1.
|
Alternative Name(s) |
Matrix metalloproteinase 14. |
Reaction catalysed |
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain |
Cofactor(s) |
Zn(2+).
|
Comment(s) |
- Believed to play an important role in the activation of progelatinase
A at cell surfaces.
- Belongs to peptidase family M10.
|
Cross-references |
PROSITE | PDOC00129 |
BRENDA | 3.4.24.80 |
EC2PDB | 3.4.24.80 |
ExplorEnz | 3.4.24.80 |
PRIAM enzyme-specific profiles | 3.4.24.80 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.80 |
IUBMB Enzyme Nomenclature | 3.4.24.80 |
IntEnz | 3.4.24.80 |
MEDLINE | Find literature relating to 3.4.24.80 |
MetaCyc | 3.4.24.80 |
Rhea expert-curated reactions | 3.4.24.80 |
UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.24.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-