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ENZYME entry: EC 3.4.24.80

Accepted Name
Membrane-type matrix metalloproteinase-1.
Alternative Name(s)
Matrix metalloproteinase 14.
Reaction catalysed
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain
Cofactor(s)
Zn(2+).
Comment(s)
  • Believed to play an important role in the activation of progelatinase A at cell surfaces.
  • Belongs to peptidase family M10.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.80
EC2PDB3.4.24.80
ExplorEnz3.4.24.80
PRIAM enzyme-specific profiles3.4.24.80
KEGG Ligand Database for Enzyme Nomenclature3.4.24.80
IUBMB Enzyme Nomenclature3.4.24.80
IntEnz3.4.24.80
MEDLINEFind literature relating to 3.4.24.80
MetaCyc3.4.24.80
Rhea expert-curated reactions3.4.24.80
UniProtKB/Swiss-Prot
Q9GLE4, MMP14_BOVIN;  P50281, MMP14_HUMAN;  P53690, MMP14_MOUSE;  
Q9XT90, MMP14_PIG;  Q5RES1, MMP14_PONAB;  Q95220, MMP14_RABIT;  
Q10739, MMP14_RAT;  

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