A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.24.84
| Accepted Name |
|---|
| Ste24 endopeptidase.
|
| Alternative Name(s) |
|---|
| CAAX prenyl protease 1. |
| Prenyl protein-specific endoprotease 1. |
| Reaction catalysed |
|---|
| The peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids |
| Cofactor(s) |
|---|
| Zn(2+).
|
| Comment(s) |
|---|
- One of two enzymes that can catalyze this processing step for mating
a-factor in Saccharomyces cerevisiae.
- Subsequently, the S-isoprenylated cysteine residue that forms the new
C-terminus is methyl-esterified and forms a hydrophobic membrane-
anchor.
- Belongs to peptidase family M48.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.24.84 |
| EC2PDB | 3.4.24.84 |
| ExplorEnz | 3.4.24.84 |
| PRIAM enzyme-specific profiles | 3.4.24.84 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.84 |
| IUBMB Enzyme Nomenclature | 3.4.24.84 |
| IntEnz | 3.4.24.84 |
| MEDLINE | Find literature relating to 3.4.24.84 |
| MetaCyc | 3.4.24.84 |
| UniProtKB/Swiss-Prot |
|
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