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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.24.84

Accepted Name
Ste24 endopeptidase.
Alternative Name(s)
CAAX prenyl protease 1.
Prenyl protein-specific endoprotease 1.
Reaction catalysed
The peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids
Cofactor(s)
Zn(2+).
Comment(s)
  • One of two enzymes that can catalyze this processing step for mating a-factor in Saccharomyces cerevisiae.
  • Subsequently, the S-isoprenylated cysteine residue that forms the new C-terminus is methyl-esterified and forms a hydrophobic membrane- anchor.
  • Belongs to peptidase family M48.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.84
EC2PDB3.4.24.84
ExplorEnz3.4.24.84
PRIAM enzyme-specific profiles3.4.24.84
KEGG Ligand Database for Enzyme Nomenclature3.4.24.84
IUBMB Enzyme Nomenclature3.4.24.84
IntEnz3.4.24.84
MEDLINEFind literature relating to 3.4.24.84
MetaCyc3.4.24.84
UniProtKB/Swiss-Prot
Q8RX88, FACE1_ARATH;  Q9XVE5, FACE1_CAEEL;  Q54FH7, FACE1_DICDI;  
O75844, FACE1_HUMAN;  Q80W54, FACE1_MOUSE;  Q6EPN8, FACE1_ORYSJ;  
Q3Y6B8, FACE_TAESO;  Q10071, STE24_SCHPO;  P47154, STE24_YEAST;  

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