ID   3.4.24.86
DE   ADAM 17 endopeptidase.
AN   TACE.
AN   tumor necrosis factor alpha-converting enzyme.
CA   Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-
CA   Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis
CA   factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-
CA   surface proteins to 'shed' the extracellular domains.
CC   -!- In vivo, the cleavage of tumor necrosis factor alpha precursor
CC       releases the soluble, 17-kDa TNF-alpha, which induces inflammation.
CC   -!- Belongs to peptidase family M12.
DR   P78536, ADA17_HUMAN;  Q9Z0F8, ADA17_MOUSE;  O77636, ADA17_PIG  ;
DR   Q9Z1K9, ADA17_RAT  ;
//