ID 3.4.25.1 DE proteasome endopeptidase complex. AN ingensin. AN Lens neutral proteinase. AN macropain. AN multicatalytic endopeptidase complex. AN multicatalytic proteinase (complex). AN prosome. AN proteasome. CA Cleavage of peptide bonds with very broad specificity. CC -!- A 20-S protein composed of 28 subunits arranged in four rings of CC seven. CC -!- The outer rings are composed of alpha subunits, but the beta subunits CC forming the inner rings are responsible for peptidase activity. CC -!- In eukaryotic organisms there are up to seven different types of beta CC subunits, three of which may carry the N-terminal threonine residues CC that are the nucleophiles in catalysis, and show different CC specificities. CC -!- The molecule is barrel-shaped, and the active sites are on the inner CC surfaces. CC -!- Terminal apertures restrict access of substrates to the active sites. CC -!- Inhibited by mercurial reagents and some inhibitors of serine CC endopeptidases. CC -!- Belongs to peptidase family T1. CC -!- Formerly EC 3.4.22.21, EC 3.4.24.5 and EC 3.4.99.46. DR Q5B7I7, INPE_EMENI ; A7KE01, PB6LA_SALSA; A7KII6, PB6LB_SALSA; DR Q9XUV0, PBS5_CAEEL ; Q3T0T1, PSB10_BOVIN; P40306, PSB10_HUMAN; DR O35955, PSB10_MOUSE; Q4KM35, PSB10_RAT ; A5LHX3, PSB11_HUMAN; DR Q8BG41, PSB11_MOUSE; Q9YES4, PSB1_AERPE ; A8MBW0, PSB1_CALMQ ; DR A0RU86, PSB1_CENSY ; B8D673, PSB1_DESA1 ; Q8SR11, PSB1_ENCCU ; DR Q5V4S6, PSB1_HALMA ; D2RQX3, PSB1_HALTV ; A2BN24, PSB1_HYPBU ; DR A8AA46, PSB1_IGNH4 ; B1L6S7, PSB1_KORCO ; A4YIE0, PSB1_METS5 ; DR A9A4A1, PSB1_NITMS ; Q9V247, PSB1_PYRAB ; Q8ZYF2, PSB1_PYRAE ; DR A4WH05, PSB1_PYRAR ; A3MS44, PSB1_PYRCJ ; Q8U4C9, PSB1_PYRFU ; DR O57983, PSB1_PYRHO ; A1RSJ8, PSB1_PYRIL ; B1YA36, PSB1_PYRNV ; DR Q53079, PSB1_RHOER ; Q980L4, PSB1_SACS2 ; D0KRX1, PSB1_SACS9 ; DR A4X3P0, PSB1_SALTO ; O43063, PSB1_SCHPO ; A3DN21, PSB1_STAMF ; DR Q82JE3, PSB1_STRAW ; Q4JAY3, PSB1_SULAC ; C3N5N4, PSB1_SULIA ; DR D2PK63, PSB1_SULID ; C4KHB0, PSB1_SULIK ; C3MQ16, PSB1_SULIL ; DR C3MVD5, PSB1_SULIM ; C3NFX2, PSB1_SULIN ; C3NE98, PSB1_SULIY ; DR Q975U8, PSB1_SULTO ; D1A2S9, PSB1_THECD ; C5A7L1, PSB1_THEGJ ; DR Q5JDJ9, PSB1_THEKO ; B6YSW2, PSB1_THEON ; A1RWY6, PSB1_THEPD ; DR C6A2V9, PSB1_THESM ; P38624, PSB1_YEAST ; Q9YER0, PSB2_AERPE ; DR A8M8R5, PSB2_CALMQ ; A0RXV1, PSB2_CENSY ; B8D683, PSB2_DESA1 ; DR Q8SQN7, PSB2_ENCCU ; Q5V1D5, PSB2_HALMA ; D2RUI0, PSB2_HALTV ; DR A2BN27, PSB2_HYPBU ; A8AB58, PSB2_IGNH4 ; B1L6X8, PSB2_KORCO ; DR A4YJ04, PSB2_METS5 ; A9A2U7, PSB2_NITMS ; Q9V0N9, PSB2_PYRAB ; DR Q8ZST5, PSB2_PYRAE ; A4WMZ0, PSB2_PYRAR ; A3MXQ6, PSB2_PYRCJ ; DR Q8U125, PSB2_PYRFU ; O50110, PSB2_PYRHO ; A1RTI7, PSB2_PYRIL ; DR B1YDJ0, PSB2_PYRNV ; Q53083, PSB2_RHOER ; Q9UXF3, PSB2_SACS2 ; DR D0KTH0, PSB2_SACS9 ; A4X744, PSB2_SALTO ; Q09841, PSB2_SCHPO ; DR A3DN27, PSB2_STAMF ; Q828I8, PSB2_STRAW ; Q4JAA8, PSB2_SULAC ; DR C3MZI0, PSB2_SULIA ; D2PDG6, PSB2_SULID ; C4KIR0, PSB2_SULIK ; DR C3MRE5, PSB2_SULIL ; C3MY41, PSB2_SULIM ; C3NHF1, PSB2_SULIN ; DR C3N7K2, PSB2_SULIY ; Q975D1, PSB2_SULTO ; D1A3V2, PSB2_THECD ; DR C5A2D5, PSB2_THEGJ ; Q5JHL8, PSB2_THEKO ; B6YXV3, PSB2_THEON ; DR A1RX71, PSB2_THEPD ; C6A3R1, PSB2_THESM ; P25043, PSB2_YEAST ; DR O23717, PSB5A_ARATH; Q9LIP2, PSB5B_ARATH; Q32KL2, PSB5_BOVIN ; DR P34065, PSB5_CHICK ; Q54BC8, PSB5_DICDI ; P28074, PSB5_HUMAN ; DR O55234, PSB5_MOUSE ; Q5R8S2, PSB5_PONAB ; P28075, PSB5_RAT ; DR P30655, PSB5_SCHPO ; O24361, PSB5_SPIOL ; P30656, PSB5_YEAST ; DR Q8LD27, PSB6_ARATH ; Q3MHN0, PSB6_BOVIN ; Q55GJ6, PSB6_DICDI ; DR P28072, PSB6_HUMAN ; Q60692, PSB6_MOUSE ; P28073, PSB6_RAT ; DR P93395, PSB6_TOBAC ; O23710, PSB7A_ARATH; Q7DLS1, PSB7B_ARATH; DR Q2TBP0, PSB7_BOVIN ; Q54QR2, PSB7_DICDI ; Q99436, PSB7_HUMAN ; DR P70195, PSB7_MOUSE ; A1XQU1, PSB7_PIG ; Q9JHW0, PSB7_RAT ; DR Q3T112, PSB8_BOVIN ; Q5W416, PSB8_CANLF ; P28062, PSB8_HUMAN ; DR P28063, PSB8_MOUSE ; Q29576, PSB8_PIG ; P28064, PSB8_RAT ; DR Q3SZC2, PSB9_BOVIN ; P28065, PSB9_HUMAN ; P28076, PSB9_MOUSE ; DR O35522, PSB9_MUSMB ; O35523, PSB9_MUSPL ; O35524, PSB9_MUSSI ; DR O35521, PSB9_MUSTR ; Q9PT26, PSB9_ONCMY ; Q8UW64, PSB9_ORYLA ; DR P28077, PSB9_RAT ; Q9DD33, PSB9_SALSA ; B5IEE5, PSB_ACIB4 ; DR A0LU50, PSB_ACIC1 ; C7LYP7, PSB_ACIFD ; C6WID8, PSB_ACTMD ; DR Q9P996, PSB_ARCFU ; D2RGT4, PSB_ARCPA ; A0JWY6, PSB_ARTS2 ; DR C5BVA2, PSB_BEUC1 ; C7PVV2, PSB_CATAD ; D3RX66, PSB_FERPA ; DR Q0RLT7, PSB_FRAAA ; Q2J9Q3, PSB_FRACC ; A8LH54, PSB_FRASN ; DR D2S6E2, PSB_GEOOG ; D0LDT1, PSB_GORB4 ; B9LTS6, PSB_HALLT ; DR C7NVQ4, PSB_HALMD ; B0R4C8, PSB_HALS3 ; Q9HR36, PSB_HALSA ; DR C7NQ99, PSB_HALUD ; D4GYZ1, PSB_HALVD ; Q18GX3, PSB_HALWD ; DR C7R403, PSB_JONDD ; A6W970, PSB_KINRD ; D2Q4H4, PSB_KRIFD ; DR A6UT20, PSB_META3 ; Q8TJB5, PSB_METAC ; Q0W2D6, PSB_METAR ; DR A7I841, PSB_METB6 ; Q46G14, PSB_METBF ; Q12YV7, PSB_METBU ; DR C7P6N4, PSB_METFA ; Q2FQL8, PSB_METHJ ; Q58634, PSB_METJA ; DR Q8TW10, PSB_METKA ; A2SS78, PSB_METLZ ; A4FYA5, PSB_METM5 ; DR A9A788, PSB_METM6 ; A6VK02, PSB_METM7 ; Q8PZ04, PSB_METMA ; DR A3CUS9, PSB_METMJ ; Q6LZD4, PSB_METMP ; D5EAS6, PSB_METMS ; DR B8GG66, PSB_METPE ; D1Z199, PSB_METPS ; D3E0A3, PSB_METRM ; DR A5UM14, PSB_METS3 ; D3S8M7, PSB_METSF ; Q2NI68, PSB_METST ; DR Q9P992, PSB_METTE ; O27270, PSB_METTH ; A0B5B1, PSB_METTP ; DR C9REN7, PSB_METVM ; A6USJ3, PSB_METVS ; A0QFB5, PSB_MYCA1 ; DR B1MAI2, PSB_MYCA9 ; Q7TZ13, PSB_MYCBO ; A1KKF3, PSB_MYCBP ; DR C1AQ26, PSB_MYCBT ; A4TB64, PSB_MYCGI ; B8ZRF3, PSB_MYCLB ; DR Q49780, PSB_MYCLE ; B2HFV6, PSB_MYCMM ; Q73YW8, PSB_MYCPA ; DR A0QZ47, PSB_MYCS2 ; A3Q193, PSB_MYCSJ ; A1UHS7, PSB_MYCSK ; DR Q1B797, PSB_MYCSS ; A5U4D6, PSB_MYCTA ; A5WP84, PSB_MYCTF ; DR C6DPV1, PSB_MYCTK ; P9WHT8, PSB_MYCTO ; P9WHT9, PSB_MYCTU ; DR A0PQT3, PSB_MYCUA ; A1TAP4, PSB_MYCVP ; C8XAQ4, PSB_NAKMY ; DR Q74MP5, PSB_NANEQ ; D3SSQ6, PSB_NATMM ; Q3IPX1, PSB_NATPD ; DR Q5YUX2, PSB_NOCFA ; A1SK13, PSB_NOCSJ ; A1R6Q7, PSB_PAEAT ; DR Q6L181, PSB_PICTO ; B8H8L6, PSB_PSECP ; A9WSI1, PSB_RENSM ; DR C0ZZU7, PSB_RHOE4 ; Q0SIF9, PSB_RHOJR ; C1ASP7, PSB_RHOOB ; DR A4FBY1, PSB_SACEN ; C7MWV7, PSB_SACVD ; A8M2A3, PSB_SALAI ; DR D1BHT9, PSB_SANKS ; D3Q557, PSB_STANL ; Q7AKQ5, PSB_STRCO ; DR B1W306, PSB_STRGG ; D2ATV1, PSB_STRRD ; C9Z4D0, PSB_STRSW ; DR P28061, PSB_THEAC ; Q47NZ4, PSB_THEFY ; Q97AZ7, PSB_THEVO ; DR D1BS26, PSB_XYLCX ; //