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ENZYME

ENZYME entry: EC 3.4.25.2

Accepted Name
HslU--HslV peptidase
Reaction catalysed
ATP-dependent cleavage of peptide bonds with broad specificity
Comment(s)
  • The HslU subunit of the HslU--HslV complex functions as an ATP dependent 'unfoldase'.
  • The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.
  • HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
  • Belongs to peptidase family T1.
Cross-references
BRENDA3.4.25.2
EC2PDB3.4.25.2
ExplorEnz3.4.25.2
PRIAM enzyme-specific profiles3.4.25.2
KEGG Ligand Database for Enzyme Nomenclature3.4.25.2
IUBMB Enzyme Nomenclature3.4.25.2
IntEnz3.4.25.2
MEDLINEFind literature relating to 3.4.25.2
MetaCyc3.4.25.2
Rhea expert-curated reactions3.4.25.2
UniProtKB/Swiss-Prot
A5FYD8, HSLV_ACICJB9MFS3, HSLV_ACIETA3N334, HSLV_ACTP2
B3GYW3, HSLV_ACTP7B0BSG5, HSLV_ACTPJA6VL80, HSLV_ACTSZ
A0KQI7, HSLV_AERHHA4SHM2, HSLV_AERS4B6JAL5, HSLV_AFIC5
Q8UJ88, HSLV_AGRFCQ21SV8, HSLV_ALBFTQ0VMA6, HSLV_ALCBS
A8ETF7, HSLV_ALIB4B5FBL7, HSLV_ALIFMQ0ACL4, HSLV_ALKEH
B9JXW5, HSLV_ALLAMB3EU68, HSLV_AMOA5B8JES1, HSLV_ANAD2
Q2ILD4, HSLV_ANADEA7HDU3, HSLV_ANADFQ5P9Z6, HSLV_ANAMM
Q2GJ25, HSLV_ANAPZB4UIH9, HSLV_ANASKB7GGC6, HSLV_ANOFW
O67587, HSLV_AQUAEQ5P502, HSLV_AROAEA1K2I5, HSLV_AZOSB
C3P5N2, HSLV_BACAAC3L797, HSLV_BACACA0RHK3, HSLV_BACAH
Q81WK5, HSLV_BACANB7JJA8, HSLV_BACC0P61476, HSLV_BACC1
B7IUI9, HSLV_BACC2C1EP54, HSLV_BACC3B7HDV3, HSLV_BACC4
B7HLG3, HSLV_BACC7A7GRG0, HSLV_BACCNB9IVB9, HSLV_BACCQ
Q819X6, HSLV_BACCRQ636J6, HSLV_BACCZQ6HEY5, HSLV_BACHK
A9VT68, HSLV_BACMKQ6G5G1, HSLV_BARHEQ6G0Q0, HSLV_BARQU
Q1LTT6, HSLV_BAUCHQ2L1C6, HSLV_BORA1Q0SNL5, HSLV_BORAP
Q7WQZ3, HSLV_BORBRQ57209, HSLV_BORBUB7J1M4, HSLV_BORBZ
B5RLC2, HSLV_BORDLQ661W9, HSLV_BORGPB2S007, HSLV_BORHD
Q7W215, HSLV_BORPAA9IH51, HSLV_BORPDQ7VUK0, HSLV_BORPE
B5RRB6, HSLV_BORRAA1QZ92, HSLV_BORT9Q89WM9, HSLV_BRADU
A5E8F2, HSLV_BRASBA4YJV0, HSLV_BRASOC0ZFA7, HSLV_BREBN
B2S979, HSLV_BRUA1Q2YQZ3, HSLV_BRUA2A6WX57, HSLV_BRUA4
Q57AH8, HSLV_BRUABA9M9R4, HSLV_BRUC2C0RFW8, HSLV_BRUMB
Q8YE31, HSLV_BRUMEA5VT38, HSLV_BRUO2B0CJI0, HSLV_BRUSI
Q8FY11, HSLV_BRUSUP57115, HSLV_BUCAIQ8K906, HSLV_BUCAP
P59581, HSLV_BUCBPQ056X3, HSLV_BUCCCB1YPR2, HSLV_BURA4
A0KBG2, HSLV_BURCHB4E7Z2, HSLV_BURCJQ0BAX9, HSLV_BURCM
Q39BY1, HSLV_BURL3A9AC32, HSLV_BURM1Q62EZ9, HSLV_BURMA
B1K0G1, HSLV_BURO0Q1BSM9, HSLV_BURO1A3NQ63, HSLV_BURP0
Q63YI3, HSLV_BURPSA4JIR2, HSLV_BURVGB9MM31, HSLV_CALBD
Q8R9Y2, HSLV_CALS4A4XIW9, HSLV_CALS8A7ZDF4, HSLV_CAMC1
A7GYN6, HSLV_CAMC5A0RPN4, HSLV_CAMFFA7I279, HSLV_CAMHC
A8FL81, HSLV_CAMJ8A7H4F1, HSLV_CAMJDQ9PHK9, HSLV_CAMJE
A1VZ22, HSLV_CAMJJQ5HVB1, HSLV_CAMJRB9KG99, HSLV_CAMLR
Q3AB73, HSLV_CARHZB0T7B0, HSLV_CAUSKQ9A239, HSLV_CAUVC
B3PI66, HSLV_CELJUA3PG34, HSLV_CERS1Q3J6B2, HSLV_CERS4
A4WWS1, HSLV_CERS5B9KRG9, HSLV_CERSKQ11CL2, HSLV_CHESB
Q3ASH7, HSLV_CHLCHB3ECB1, HSLV_CHLL2Q3B4D9, HSLV_CHLL3
B3QNN5, HSLV_CHLP8B3EJG6, HSLV_CHLPBA1BGP1, HSLV_CHLPD
A4SER5, HSLV_CHLPMQ8KD62, HSLV_CHLTEQ7P113, HSLV_CHRVO
A9KH30, HSLV_COXBNA9N9F9, HSLV_COXBRQ83A95, HSLV_COXBU
Q1LS59, HSLV_CUPMCQ0KF70, HSLV_CUPNHQ476Y4, HSLV_CUPPJ
B2AGB6, HSLV_CUPTRQ11UQ9, HSLV_CYTH3Q47JL9, HSLV_DECAR
A9BUJ5, HSLV_DELASB1I260, HSLV_DESAPB8J0S4, HSLV_DESDA
B8FRG9, HSLV_DESHDQ24UF3, HSLV_DESHYA4J5Z6, HSLV_DESRM
A5EX24, HSLV_DICNVA8LPA8, HSLV_DINSHA7ZUE7, HSLV_ECO24
B7UNQ2, HSLV_ECO27B7MI64, HSLV_ECO45B7LA29, HSLV_ECO55
P0A7C0, HSLV_ECO57B5YZ72, HSLV_ECO5EB7NU73, HSLV_ECO7I
B7MR21, HSLV_ECO81B7M6Y3, HSLV_ECO8AC5A099, HSLV_ECOBW
B1XB98, HSLV_ECODHA8A738, HSLV_ECOHSA1AIA7, HSLV_ECOK1
Q0TAD2, HSLV_ECOL5P0A7B9, HSLV_ECOL6B1IVE7, HSLV_ECOLC
P0A7B8, HSLV_ECOLIB7NFN1, HSLV_ECOLUB6I4S5, HSLV_ECOSE
B1LNN7, HSLV_ECOSMQ1R3Y5, HSLV_ECOUTQ3YR20, HSLV_EHRCJ
Q2GFK0, HSLV_EHRCRQ5FGD0, HSLV_EHRRGQ5HAB3, HSLV_EHRRW
A4WG66, HSLV_ENT38Q834K3, HSLV_ENTFAB2VF49, HSLV_ERWT9
B7LUS2, HSLV_ESCF3C1ABE1, HSLV_GEMATQ5L0N2, HSLV_GEOKA
C5D8V8, HSLV_GEOSWA4IM88, HSLV_GEOTNB8F689, HSLV_GLAP5
Q7VKB4, HSLV_HAEDUQ4QN50, HSLV_HAEI8A5U9Z6, HSLV_HAEIE
A5UH05, HSLV_HAEIGP43772, HSLV_HAEINQ2S9P4, HSLV_HAHCH
Q9KA26, HSLV_HALH5A1WWB6, HSLV_HALHLC4K5T1, HSLV_HAMD5
Q17XG1, HSLV_HELAHQ7VJD3, HSLV_HELHPB6JL97, HSLV_HELP2
B5Z6N8, HSLV_HELPGQ1CU16, HSLV_HELPHQ9ZLW2, HSLV_HELPJ
B2UTX3, HSLV_HELPSO25253, HSLV_HELPYA4G989, HSLV_HERAR
Q0I5E1, HSLV_HISS1B0US06, HSLV_HISS2Q31IL7, HSLV_HYDCU
Q0C0L2, HSLV_HYPNAQ5QV35, HSLV_IDILOA6T306, HSLV_JANMA
Q28W10, HSLV_JANSCB5XZ36, HSLV_KLEP3A6TGC2, HSLV_KLEP7
Q1IV81, HSLV_KORVEB3WEA8, HSLV_LACCBQ48734, HSLV_LACLE
Q039E0, HSLV_LACP3Q88W25, HSLV_LACPLQ1MQE1, HSLV_LAWIP
Q5X7B1, HSLV_LEGPAA5IGR7, HSLV_LEGPCQ5ZXU1, HSLV_LEGPH
Q5WYQ9, HSLV_LEGPLB0SCD1, HSLV_LEPBAQ04TA2, HSLV_LEPBJ
Q051M4, HSLV_LEPBLQ8GQU1, HSLV_LEPBOB0SKV3, HSLV_LEPBP
B1Y6R3, HSLV_LEPCPQ72RY8, HSLV_LEPICQ8F3Q4, HSLV_LEPIN
Q1WTI9, HSLV_LIGS1Q92C74, HSLV_LISINC1L2I6, HSLV_LISMC
Q720E3, HSLV_LISMFB8DG53, HSLV_LISMHQ8Y7J9, HSLV_LISMO
A0AI81, HSLV_LISW6B1HQJ5, HSLV_LYSSCB9EBD3, HSLV_MACCJ
A0L3K3, HSLV_MAGMMP49617, HSLV_MANHAQ65VY2, HSLV_MANSM
A6W2U5, HSLV_MARMSA1TYU6, HSLV_MARN8C6C0P0, HSLV_MARSD
B7KZ47, HSLV_METC4Q606K2, HSLV_METCAA9W0F2, HSLV_METEP
A2SLA3, HSLV_METPPQ2RJP6, HSLV_MOOTAQ84F94, HSLV_MYXXA
Q1D802, HSLV_MYXXDQ2GEM5, HSLV_NEOSMQ0AD36, HSLV_NITEC
Q82SP7, HSLV_NITEUQ1QRX5, HSLV_NITHXQ3J8P8, HSLV_NITOC
A6Q3Q1, HSLV_NITSBQ72BQ7, HSLV_NITV2A1VDQ7, HSLV_NITV4
B8DKL3, HSLV_NITV9Q3SWE6, HSLV_NITWNQ8CXH2, HSLV_OCEIH
Q30ZH5, HSLV_OLEA2A1B5T1, HSLV_PARDPA7HSH6, HSLV_PARL1
Q2VYI5, HSLV_PARM1B2JJX8, HSLV_PARP8B2T1N9, HSLV_PARPJ
Q146W9, HSLV_PARXLP57969, HSLV_PASMUQ6CZ92, HSLV_PECAS
C6DHM7, HSLV_PECCPQ03FK3, HSLV_PEDPAB4SGR7, HSLV_PELPB
A5D2W7, HSLV_PELTSC0QS72, HSLV_PERMHA9BI45, HSLV_PETMO
Q7MYC2, HSLV_PHOLLQ6LVI2, HSLV_PHOPRB4S817, HSLV_PROA2
B4F172, HSLV_PROMHQ48PI4, HSLV_PSE14Q15N48, HSLV_PSEA6
A6VDH4, HSLV_PSEA7B7V3E6, HSLV_PSEA8Q02EW4, HSLV_PSEAB
Q9HUC6, HSLV_PSEAEQ1I3U0, HSLV_PSEE4Q4KJK2, HSLV_PSEF5
C3KAH1, HSLV_PSEFSA8F5A7, HSLV_PSELTA4XPN7, HSLV_PSEMY
Q88D28, HSLV_PSEPKQ87V01, HSLV_PSESMA1SQW4, HSLV_PSYIN
Q8Y3D7, HSLV_RALN1B2U7X2, HSLV_RALPJB3PWI6, HSLV_RHIE6
Q2KE55, HSLV_RHIECQ1MNB5, HSLV_RHIJ3Q98CT8, HSLV_RHILO
B5ZV98, HSLV_RHILWQ92TA9, HSLV_RHIMEB9JG70, HSLV_RHIR8
A5VEJ8, HSLV_RHIWRP61477, HSLV_RHOPAC3PN29, HSLV_RICAE
A8GMZ9, HSLV_RICAHA8GWX0, HSLV_RICB8Q1RIB6, HSLV_RICBR
A8EZD3, HSLV_RICCKQ92II7, HSLV_RICCNQ4UM54, HSLV_RICFE
Q9ZDK9, HSLV_RICPRC4K1X3, HSLV_RICPUB0BX21, HSLV_RICRO
A8GRL7, HSLV_RICRSQ68X53, HSLV_RICTYQ16CY0, HSLV_ROSDO
Q5LLP2, HSLV_RUEPOQ1GCN5, HSLV_RUESTQ21H72, HSLV_SACD2
B5F0S3, HSLV_SALA4Q57HC5, HSLV_SALCHB5FPU1, HSLV_SALDC
B5QXM1, HSLV_SALEPB5RF79, HSLV_SALG2B4TCM9, HSLV_SALHS
B4T0T9, HSLV_SALNSQ5PK45, HSLV_SALPAA9MZI2, HSLV_SALPB
C0Q442, HSLV_SALPCB5BJK9, HSLV_SALPKB4TPV3, HSLV_SALSV
P0A272, HSLV_SALTIP0A271, HSLV_SALTYA8GL95, HSLV_SERP5
A1S2P5, HSLV_SHEAMB8E6E4, HSLV_SHEB2A3D9C5, HSLV_SHEB5
A6WIH6, HSLV_SHEB8A9KYP9, HSLV_SHEB9Q12IT9, HSLV_SHEDO
Q07WM3, HSLV_SHEFNB0TVV3, HSLV_SHEHHA3Q9U9, HSLV_SHELP
Q8E9V0, HSLV_SHEONA8H955, HSLV_SHEPAA4Y2S8, HSLV_SHEPC
B8CI19, HSLV_SHEPWA0L1J8, HSLV_SHESAA8FQM0, HSLV_SHESH
Q0HED1, HSLV_SHESMQ0HZL8, HSLV_SHESRB1KK50, HSLV_SHEWM
B2TWC8, HSLV_SHIB3Q31U58, HSLV_SHIBSQ32AA5, HSLV_SHIDS
Q0SY57, HSLV_SHIF8P0A7C1, HSLV_SHIFLQ3YV46, HSLV_SHISS
Q5WFQ0, HSLV_SHOC1C3MBC6, HSLV_SINFNA6UEK8, HSLV_SINMW
Q2NQY2, HSLV_SODGMC4XN25, HSLV_SOLM1Q01Q19, HSLV_SOLUE
A7X1M9, HSLV_STAA1A6U171, HSLV_STAA2Q2FHI5, HSLV_STAA3
Q2FZ29, HSLV_STAA8A5ISD7, HSLV_STAA9Q2YXL5, HSLV_STAAB
Q5HGH9, HSLV_STAACA6QGF3, HSLV_STAAEP65796, HSLV_STAAM
P65797, HSLV_STAANQ6GHI2, HSLV_STAARQ6G9W0, HSLV_STAAS
A8Z3T3, HSLV_STAATP65798, HSLV_STAAWB9DPG5, HSLV_STACT
Q5HPT9, HSLV_STAEQQ8CPH1, HSLV_STAESQ4L5V5, HSLV_STAHJ
Q49X38, HSLV_STAS1B4SJN0, HSLV_STRM5B2FUV7, HSLV_STRMK
Q30QS8, HSLV_SULDNA6QAX2, HSLV_SULNBB2V939, HSLV_SULSY
Q3A1V7, HSLV_SYNC1A0LEB7, HSLV_SYNFMQ0AYP2, HSLV_SYNWW
C5BRK9, HSLV_TERTTB7IFU1, HSLV_THEABA6LJK3, HSLV_THEM4
Q9WYZ1, HSLV_THEMAA5IJQ3, HSLV_THEP1B0K9V4, HSLV_THEP3
B0K1T7, HSLV_THEPXB1L8X4, HSLV_THESQB5YFZ9, HSLV_THEYD
Q3SFW2, HSLV_THIDAB8GTA0, HSLV_THISHC4L9X0, HSLV_TOLAT
P61478, HSLV_TREDEQ383Q5, HSLV_TRYB2C5CNE3, HSLV_VARPS
A1WRK0, HSLV_VEREIB7VLM6, HSLV_VIBA3A7MWJ4, HSLV_VIBC1
A5F4X4, HSLV_VIBC3Q9KNQ6, HSLV_VIBCHC3LSA4, HSLV_VIBCM
Q87T20, HSLV_VIBPAQ8DCP3, HSLV_VIBVUQ7MH57, HSLV_VIBVY
Q8D2S6, HSLV_WIGBRP61479, HSLV_WOLPMB3CLU4, HSLV_WOLPP
Q7M8Z6, HSLV_WOLSUQ5GRR4, HSLV_WOLTRC0R4L3, HSLV_WOLWR
Q8PPP8, HSLV_XANACQ4UYX7, HSLV_XANC8Q8P551, HSLV_XANCP
Q3BXU0, HSLV_XANE5Q2NYV8, HSLV_XANOMB2IA19, HSLV_XYLF2
P65799, HSLV_XYLFAP65800, HSLV_XYLFTA1JI09, HSLV_YERE8
A7FCY5, HSLV_YERP3Q1CBE7, HSLV_YERPAB2JZC6, HSLV_YERPB
Q8ZJJ4, HSLV_YERPEA9R6C8, HSLV_YERPGQ1CD56, HSLV_YERPN
A4TS83, HSLV_YERPPQ66G84, HSLV_YERPSB1JQ75, HSLV_YERPY
Q5NQY4, HSLV_ZYMMO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.25.-
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