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ENZYME entry: EC 3.5.1.104

Accepted Name
Peptidoglycan-N-acetylglucosamine deacetylase.
Alternative Name(s)
N-acetylglucosamine deacetylase.
Peptidoglycan deacetylase.
Peptidoglycan GlcNAc deacetylase.
Peptidoglycan N-acetylglucosamine deacetylase.
Reaction catalysed
Peptidoglycan-N-acetyl-D-glucosamine + H(2)O <=> peptidoglycan-D-glucosamine + acetate
Comment(s)
  • Modification of peptidoglycan by N-deacetylation is an important factor in virulence of Helicobacter pylori, Listeria monocytogenes and Streptococcus suis.
  • The enzyme from Streptococcus pneumoniae is a metalloenzyme using a His-His-Asp zinc-binding triad with a nearby aspartic acid and histidine acting as the catalytic base and acid, respectively.
Cross-references
BRENDA3.5.1.104
EC2PDB3.5.1.104
ExplorEnz3.5.1.104
PRIAM enzyme-specific profiles3.5.1.104
KEGG Ligand Database for Enzyme Nomenclature3.5.1.104
IUBMB Enzyme Nomenclature3.5.1.104
IntEnz3.5.1.104
MEDLINEFind literature relating to 3.5.1.104
MetaCyc3.5.1.104
Rhea expert-curated reactions3.5.1.104
UniProtKB/Swiss-Prot
Q81EK9, PGDA1_BACCR;  Q81EJ6, PGDA2_BACCR;  Q81AF4, PGDA3_BACCR;  
D4B5F9, PGDA_ARTBC;  A0A0H3GDH9, PGDA_LISM4;  A0A3Q0NBH7, PGDA_LISMG;  
Q8Y9V5, PGDA_LISMO;  Q8DP63, PGDA_STRR6;  

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