ID   3.5.1.121
DE   protein N-terminal asparagine amidohydrolase.
CA   H(+) + H2O + N-terminal L-asparaginyl-[protein] = N-terminal L-aspartyl-
CA   [protein] + NH4(+).
CC   -!- This enzyme participates in the eukaryotic ubiquitin-dependent
CC       Arg/N-end rule pathway of protein degradation, promoting the turnover
CC       of intracellular proteins that initiate with Met-Asn.
CC   -!- Following the acetylation and removal of the initiator methionine,
CC       the exposed N-terminal asparagine is deaminated, resulting in its
CC       conversion to L-aspartate.
CC   -!- The latter serves as a substrate for EC 2.3.2.8 making the protein
CC       susceptible to arginylation, polyubiquitination and degradation as
CC       specified by the N-end rule.
DR   O64876, NTAN1_ARATH;  Q96AB6, NTAN1_HUMAN;  Q64311, NTAN1_MOUSE;
DR   Q28955, NTAN1_PIG  ;
//