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ENZYME

ENZYME entry: EC 3.5.1.122

PURL: https://purl.expasy.org/enzyme/EC/3.5.1.122
Accepted Name
protein N-terminal glutamine amidohydrolase
Reaction catalysed
N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4(+)
Comment(s)
  • This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Gln.
  • Following the acetylation and removal of the initiator methionine, the exposed N-terminal glutamine is deaminated, resulting in its conversion to L-glutamate.
  • The latter serves as a substrate for EC 2.3.2.8 making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.
Cross-references
BRENDA3.5.1.122
EC2PDB3.5.1.122
ExplorEnz3.5.1.122
KEGG Ligand Database for Enzyme Nomenclature3.5.1.122
IUBMB Enzyme Nomenclature3.5.1.122
MEDLINEFind literature relating to 3.5.1.122
MetaCyc3.5.1.122
Rhea expert-curated reactions3.5.1.122
UniProtKB/Swiss-Prot
Q7Q968, NTAQ1_ANOGAO22944, NTAQ1_ARATHQ3T0D3, NTAQ1_BOVIN
A8Y183, NTAQ1_CAEBRQ21775, NTAQ1_CAEELQ1LWX3, NTAQ1_DANRE
B3MCF3, NTAQ1_DROANB3NQ86, NTAQ1_DROERB4J8A0, NTAQ1_DROGR
Q7K2Y9, NTAQ1_DROMEB4KPY6, NTAQ1_DROMOQ28WL0, NTAQ1_DROPS
B4HSF8, NTAQ1_DROSEB4QGZ1, NTAQ1_DROSIB4MDT2, NTAQ1_DROVI
B4MQL4, NTAQ1_DROWIB4P6V4, NTAQ1_DROYAQ96HA8, NTAQ1_HUMAN
Q80WB5, NTAQ1_MOUSEB8AXU2, NTAQ1_ORYSIQ60E61, NTAQ1_ORYSJ
Q5BJV9, NTAQ1_RATQ5PPU8, NTAQ1_XENLA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-