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ENZYME

ENZYME entry: EC 3.5.1.124

PURL: https://purl.expasy.org/enzyme/EC/3.5.1.124
Accepted Name
protein deglycase
Alternative Name(s)
glyoxylase III
Reaction catalysed
  • N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] + H2O = lactate + L-arginyl-[protein] + H(+)
  • N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] + H2O = lactate + L-lysyl-[protein] + H(+)
  • S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] + H2O = lactate + L-cysteinyl-[protein] + H(+)
Comment(s)
  • The enzyme, previously thought to be a glyoxalase, acts on glycated L-arginine, L-lysine, and L-cysteine residues within proteins that have been attacked and modified by glyoxal or 2-oxopropanal.
  • The attack forms hemithioacetal in the case of cysteines and aminocarbinols in the case of arginines and lysines.
  • The enzyme repairs the amino acids, releasing glycolate or lactate (70-80% (S)-lactate and 20-30% (R)-lactate), depending on whether the attacking agent was glyoxal or 2-oxopropanal, respectively.
Cross-references
BRENDA3.5.1.124
EC2PDB3.5.1.124
ExplorEnz3.5.1.124
KEGG Ligand Database for Enzyme Nomenclature3.5.1.124
IUBMB Enzyme Nomenclature3.5.1.124
MEDLINEFind literature relating to 3.5.1.124
MetaCyc3.5.1.124
Rhea expert-curated reactions3.5.1.124
UniProtKB/Swiss-Prot
Q9V1F8, DEGLY_PYRABQ51732, DEGLY_PYRFUO59413, DEGLY_PYRHO
Q5JGM7, DEGLY_THEKOA7ZN88, HCHA_ECO24B7MCM0, HCHA_ECO45
B7L8Y4, HCHA_ECO55Q8XB78, HCHA_ECO57B5YSJ3, HCHA_ECO5E
B7NRB5, HCHA_ECO7IB7MWF3, HCHA_ECO81B7M3A5, HCHA_ECO8A
C4ZQN7, HCHA_ECOBWB1X6B7, HCHA_ECODHA8A1G6, HCHA_ECOHS
A1ACB2, HCHA_ECOK1Q0TGM8, HCHA_ECOL5P59331, HCHA_ECOL6
B1IZU5, HCHA_ECOLCP31658, HCHA_ECOLIB7NBV8, HCHA_ECOLU
B6I112, HCHA_ECOSEB1LQP2, HCHA_ECOSMQ1RAH5, HCHA_ECOUT
B7UX51, HCHA_PSEA8Q02IV5, HCHA_PSEABQ9I4K0, HCHA_PSEAE
B2TWL8, HCHA_SHIB3Q0T3G3, HCHA_SHIF8P59332, HCHA_SHIFL
Q3Z0M5, HCHA_SHISSA7WYY0, HCHA_STAA1A6TZ28, HCHA_STAA2
Q2FJ89, HCHA_STAA3Q2G0M7, HCHA_STAA8A5IQA5, HCHA_STAA9
Q2YSB0, HCHA_STAABQ5HIC4, HCHA_STAACA6QEK3, HCHA_STAAE
P64312, HCHA_STAAMP64313, HCHA_STAANQ6GJB7, HCHA_STAAR
Q6GBT6, HCHA_STAASA8YZP8, HCHA_STAATQ8NXY2, HCHA_STAAW
Q5E946, PARK7_BOVINQ8UW59, PARK7_CHICKQ95LI9, PARK7_CHLAE
Q5XJ36, PARK7_DANREQ99497, PARK7_HUMANQ7TQ35, PARK7_MESAU
Q99LX0, PARK7_MOUSEO88767, PARK7_RATQ46948, YAJL_ECOLI
P55880, YAJL_SALTYP45470, YHBO_ECOLI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-