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ENZYME entry: EC 3.5.1.79

Accepted Name
Phthalyl amidase.
Alternative Name(s)
o-phthalyl amidase.
Reaction catalysed
A phthalylamide + H(2)O <=> phthalic acid + a substituted amine
Comment(s)
  • Phthalyl is used to mean 2-carboxybenzoyl.
  • The enzyme from Xanthobacter agilis hydrolyzes phthalylated amino acids, peptides, beta-lactams, aromatic and aliphatic amines.
  • The substituent on nitrogen may be an alkyl group, but may also be complex, giving an amino acid or peptide derivative.
  • Substitutions on the phthalyl ring include 6-F, 6-NH(2), 3-OH, and a nitrogen in the aromatic ring ortho to the carboxy group attached to the amine.
Cross-references
BRENDA3.5.1.79
EC2PDB3.5.1.79
ExplorEnz3.5.1.79
PRIAM enzyme-specific profiles3.5.1.79
KEGG Ligand Database for Enzyme Nomenclature3.5.1.79
IUBMB Enzyme Nomenclature3.5.1.79
IntEnz3.5.1.79
MEDLINEFind literature relating to 3.5.1.79
MetaCyc3.5.1.79
Rhea expert-curated reactions3.5.1.79
UniProtKB/Swiss-Prot
P0C2Y0, PHAM_XANAG

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