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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Phthalyl amidase.
Alternative Name(s)
o-phthalyl amidase.
Reaction catalysed
A phthalylamide + H(2)O <=> phthalic acid + a substituted amine
  • Phthalyl is used to mean 2-carboxybenzoyl.
  • The enzyme from Xanthobacter agilis hydrolyzes phthalylated amino acids, peptides, beta-lactams, aromatic and aliphatic amines.
  • The substituent on nitrogen may be an alkyl group, but may also be complex, giving an amino acid or peptide derivative.
  • Substitutions on the phthalyl ring include 6-F, 6-NH(2), 3-OH, and a nitrogen in the aromatic ring ortho to the carboxy group attached to the amine.
PRIAM enzyme-specific profiles3.5.1.79
KEGG Ligand Database for Enzyme Nomenclature3.5.1.79
IUBMB Enzyme Nomenclature3.5.1.79
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
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