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ENZYME entry: EC 3.5.1.89

Accepted Name
N-acetylglucosaminylphosphatidylinositol deacetylase.
Alternative Name(s)
acetylglucosaminylphosphatidylinositol deacetylase.
GlcNAc-PI deacetylase.
GlcNAc-PI de-N-acetylase.
N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase.
N-acetylglucosaminylphosphatidylinositol de-N-acetylase.
Reaction catalysed
a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O <=> acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol
Comment(s)
  • Involved in the second step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes.
  • The enzyme appears to be composed of a single subunit (PIG-L in mammalian cells and GPI12 in Saccharomyces cerevisiae).
  • In some species, the long-chain sn-1-acyl group of the phosphatidyl group is replaced by a long-chain alkyl or alk-1-enyl group.
  • Formerly EC 3.1.1.69.
Cross-references
BRENDA3.5.1.89
EC2PDB3.5.1.89
ExplorEnz3.5.1.89
PRIAM enzyme-specific profiles3.5.1.89
KEGG Ligand Database for Enzyme Nomenclature3.5.1.89
IUBMB Enzyme Nomenclature3.5.1.89
IntEnz3.5.1.89
MEDLINEFind literature relating to 3.5.1.89
MetaCyc3.5.1.89
Rhea expert-curated reactions3.5.1.89
UniProtKB/Swiss-Prot
D4B4K9, GPI12_ARTBC;  Q9HDW9, GPI12_SCHPO;  P23797, GPI12_YEAST;  
A6QQ24, PIGL_BOVIN;  Q54C64, PIGL_DICDI;  Q9Y2B2, PIGL_HUMAN;  
Q5SX19, PIGL_MOUSE;  O35790, PIGL_RAT;  

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