ENZYME entry: EC 3.5.1.89
Accepted Name |
N-acetylglucosaminylphosphatidylinositol deacetylase.
|
Alternative Name(s) |
Acetylglucosaminylphosphatidylinositol deacetylase. |
GlcNAc-PI de-N-acetylase. |
GlcNAc-PI deacetylase. |
N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase. |
N-acetylglucosaminylphosphatidylinositol de-N-acetylase. |
Reaction catalysed |
6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(2)O <=> 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate |
Comment(s) |
- Involved in the second step of glycosylphosphatidylinositol (GPI)
anchor formation in all eukaryotes.
- The enzyme appears to be composed of a single subunit (PIG-L in
mammalian cells and GPI12 in Saccharomyces cerevisiae).
- In some species, the long-chain sn-1-acyl group of the phosphatidyl
group is replaced by a long-chain alkyl or alk-1-enyl group.
- Formerly EC 3.1.1.69.
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Cross-references |
BRENDA | 3.5.1.89 |
EC2PDB | 3.5.1.89 |
ExplorEnz | 3.5.1.89 |
PRIAM enzyme-specific profiles | 3.5.1.89 |
KEGG Ligand Database for Enzyme Nomenclature | 3.5.1.89 |
IUBMB Enzyme Nomenclature | 3.5.1.89 |
IntEnz | 3.5.1.89 |
MEDLINE | Find literature relating to 3.5.1.89 |
MetaCyc | 3.5.1.89 |
Rhea expert-curated reactions | 3.5.1.89 |
UniProtKB/Swiss-Prot |
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