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ENZYME entry: EC 3.5.1.94

Accepted Name
Gamma-glutamyl-gamma-aminobutyrate hydrolase.
Alternative Name(s)
Gamma-glutamyl-GABA hydrolase.
Reaction catalysed
4-(gamma-L-glutamylamino)butanoate + H(2)O <=> 4-aminobutanoate + L-glutamate
Comment(s)
  • Forms part of a novel putrescine-utilizing pathway in Escherichia coli, in which it has been hypothesized that putrescine is first glutamylated to form gamma-glutamylputrescine, which is oxidized to 4-(gamma-glutamylamino)butanal and then to 4-(gamma- glutamylamino)butanoate.
  • Also can catalyze the reactions of EC 3.5.1.35 and EC 3.5.1.65.
Cross-references
BRENDA3.5.1.94
EC2PDB3.5.1.94
ExplorEnz3.5.1.94
PRIAM enzyme-specific profiles3.5.1.94
KEGG Ligand Database for Enzyme Nomenclature3.5.1.94
IUBMB Enzyme Nomenclature3.5.1.94
IntEnz3.5.1.94
MEDLINEFind literature relating to 3.5.1.94
MetaCyc3.5.1.94
Rhea expert-curated reactions3.5.1.94
UniProtKB/Swiss-Prot
Q8X7G2, PUUD_ECO57;  P76038, PUUD_ECOLI;  Q83LB6, PUUD_SHIFL;  
Q3Z146, PUUD_SHISS;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
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