Home  |  Contact

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Acyl-homoserine-lactone acylase.
Alternative Name(s)
Acyl-homoserine lactone acylase.
N-acyl-homoserine lactone acylase.
Quorum-quenching AHL acylase.
Quorum-quenching enzyme.
Reaction catalysed
An N-acyl-L-homoserine lactone + H(2)O <=> L-homoserine lactone + a carboxylate
  • Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing.
  • Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes.
  • Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL- signaling and the expression of virulence genes in quorum-sensing bacteria.
  • This quorum-quenching enzyme removes the fatty-acid side chain from the homoserine lactone ring of AHL-dependent quorum-sensing signal molecules.
  • It has broad specificity for AHLs with side changes ranging in length from 11 to 14 carbons.
  • Substituents at the 3'-position, as found in N-(3-oxododecanoyl)-L- homoserine lactone, do not affect this activity.
PRIAM enzyme-specific profiles3.5.1.97
KEGG Ligand Database for Enzyme Nomenclature3.5.1.97
IUBMB Enzyme Nomenclature3.5.1.97
MEDLINEFind literature relating to

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-