ID 3.5.1.98 DE histone deacetylase. AN HDAC. CA H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]. CC -!- A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine CC residues on a histone. CC -!- The reaction of this enzyme is opposite to that of EC 2.3.1.48. CC -!- Histone deacetylases (HDACs) can be organized into three classes CC depending on sequence similarity and domain organization. CC -!- Histone acetylation plays an important role in regulation of gene CC expression. CC -!- In eukaryotes, HDACs play a key role in the regulation of CC transcription and cell proliferation. CC -!- May be identical to EC 3.5.1.17. DR P56523, CLR3_SCHPO ; O59702, CLR6_SCHPO ; Q9M1N8, HDA10_ARATH; DR Q55FN5, HDA11_DICDI; Q96DB2, HDA11_HUMAN; Q9GKU5, HDA11_MACFA; DR Q91WA3, HDA11_MOUSE; Q55BW2, HDA12_DICDI; Q8GXJ1, HDA15_ARATH; DR Q9LXN8, HDA17_ARATH; Q8LRK8, HDA18_ARATH; O22446, HDA19_ARATH; DR P56521, HDA19_MAIZE; Q91695, HDA1A_XENLA; O42227, HDA1B_XENLA; DR O17695, HDA1_CAEEL ; Q5A960, HDA1_CANAL ; P53973, HDA1_YEAST ; DR Q54X15, HDA21_DICDI; Q54VQ7, HDA22_DICDI; Q944K3, HDA2_ARATH ; DR Q09440, HDA2_CAEEL ; Q613L4, HDA4_CAEBR ; O17323, HDA4_CAEEL ; DR Q8RX28, HDA5_ARATH ; Q9FML2, HDA6_ARATH ; Q20296, HDA6_CAEEL ; DR Q9FH09, HDA7_ARATH ; Q94EJ2, HDA8_ARATH ; Q6PBI4, HDA9B_DANRE; DR Q8H0W2, HDA9_ARATH ; Q32PJ8, HDAC1_BOVIN; P56517, HDAC1_CHICK; DR Q94517, HDAC1_DROME; Q13547, HDAC1_HUMAN; O09106, HDAC1_MOUSE; DR Q7Y0Y8, HDAC1_ORYSJ; Q5RAG0, HDAC1_PONAB; Q4QQW4, HDAC1_RAT ; DR P56518, HDAC1_STRPU; P56519, HDAC2_CHICK; Q92769, HDAC2_HUMAN; DR P70288, HDAC2_MOUSE; Q6YV04, HDAC2_ORYSJ; P56520, HDAC3_CHICK; DR Q803C3, HDAC3_DANRE; O15379, HDAC3_HUMAN; O88895, HDAC3_MOUSE; DR Q7Y0Y6, HDAC3_ORYSJ; Q5RB76, HDAC3_PONAB; Q6P6W3, HDAC3_RAT ; DR Q4SFA0, HDAC3_TETNG; Q6IRL9, HDAC3_XENLA; Q28DV3, HDAC3_XENTR; DR P83038, HDAC4_CHICK; P56524, HDAC4_HUMAN; Q6NZM9, HDAC4_MOUSE; DR Q99P99, HDAC4_RAT ; Q80ZH1, HDAC5_CRIGR; Q9UQL6, HDAC5_HUMAN; DR Q9Z2V6, HDAC5_MOUSE; Q5R902, HDAC5_PONAB; Q9UBN7, HDAC6_HUMAN; DR Q9Z2V5, HDAC6_MOUSE; Q8WUI4, HDAC7_HUMAN; Q8C2B3, HDAC7_MOUSE; DR Q99P96, HDAC7_RAT ; Q0VCB2, HDAC8_BOVIN; Q7SXM0, HDAC8_DANRE; DR Q9BY41, HDAC8_HUMAN; Q8VH37, HDAC8_MOUSE; B1WC68, HDAC8_RAT ; DR Q6GPA7, HDAC8_XENLA; B1H369, HDAC8_XENTR; Q5ZKH6, HDAC9_CHICK; DR Q9UKV0, HDAC9_HUMAN; Q99N13, HDAC9_MOUSE; Q9YGY4, HDAC9_XENLA; DR Q12214, HOS1_YEAST ; P53096, HOS2_YEAST ; Q02959, HOS3_YEAST ; DR O13298, PHD1_SCHPO ; P32561, RPD3_YEAST ; //