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ENZYME entry: EC 3.5.1.99

Accepted Name
fatty acid amide hydrolase.
Alternative Name(s)
anandamide amidohydrolase.
oleamide hydrolase.
Reaction catalysed
  • H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine
  • (9Z)-octadecenamide + H2O <=> (9Z)-octadecenoate + NH4(+)
Comment(s)
  • Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia.
  • Formerly EC 3.5.1.n2.
Cross-references
BRENDA3.5.1.99
EC2PDB3.5.1.99
ExplorEnz3.5.1.99
PRIAM enzyme-specific profiles3.5.1.99
KEGG Ligand Database for Enzyme Nomenclature3.5.1.99
IUBMB Enzyme Nomenclature3.5.1.99
IntEnz3.5.1.99
MEDLINEFind literature relating to 3.5.1.99
MetaCyc3.5.1.99
Rhea expert-curated reactions3.5.1.99
UniProtKB/Swiss-Prot
Q17449, FAAH1_CAEEL;  O00519, FAAH1_HUMAN;  O08914, FAAH1_MOUSE;  
Q9TUI8, FAAH1_PIG;  P97612, FAAH1_RAT;  Q6GMR7, FAAH2_HUMAN;  
Q9U217, FAAH4_CAEEL;  Q7XJJ7, FAAH_ARATH;  Q6DH69, FAH2A_DANRE;  
Q05AM4, FAH2B_DANRE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-