A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.5.4.29
| Accepted Name |
|---|
| GTP cyclohydrolase IIa.
|
| Alternative Name(s) |
|---|
| GTP cyclohydrolase III. |
| Reaction catalysed |
|---|
| GTP + 3 H(2)O <=> 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 phosphate |
| Cofactor(s) |
|---|
| Mg(2+).
|
| Comment(s) |
|---|
- This enzyme catalyzes the hydrolysis of the imidazole ring of
guanosine 5'-triphosphate, N(7)-methylguanosine 5'-triphosphate or
inosine 5'-triphosphate.
- Xanthosine 5'-triphosphate and ATP are not substrates.
- It also catalyzes the hydrolysis of diphosphate to form two
equivalents of phosphate.
- Unlike EC 3.5.4.25, this enzyme does not release formate, but does
hydrolyze the diphosphate from GTP to phosphate.
|
| Cross-references |
|---|
| BRENDA | 3.5.4.29 |
| EC2PDB | 3.5.4.29 |
| ExplorEnz | 3.5.4.29 |
| PRIAM enzyme-specific profiles | 3.5.4.29 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.5.4.29 |
| IUBMB Enzyme Nomenclature | 3.5.4.29 |
| IntEnz | 3.5.4.29 |
| MEDLINE | Find literature relating to 3.5.4.29 |
| MetaCyc | 3.5.4.29 |
| UniProtKB/Swiss-Prot |
| Q9HQT7, GCH31_HALSA; | Q9HQS9, GCH32_HALSA; | Q9YC89, GCH3_AERPE; |
| B9LRB1, GCH3_HALLT; | Q57609, GCH3_METJA; | A4FZ97, GCH3_METM5; |
| A9A6P4, GCH3_METM6; | A6VJ40, GCH3_METM7; | Q6M066, GCH3_METMP; |
| A5ULV0, GCH3_METS3; | Q2NEH8, GCH3_METST; | O27096, GCH3_METTH; |
| A6US18, GCH3_METVS; | Q3INZ0, GCH3_NATPD; | Q8ZU20, GCH3_PYRAE; |
| A4WKJ7, GCH3_PYRAR; | A3MV81, GCH3_PYRCJ; | A1RRI0, GCH3_PYRIL; |
| B1YAW1, GCH3_PYRNV; | C3MZ63, GCH3_SULIA; | C4KIE1, GCH3_SULIK; |
| C3MR15, GCH3_SULIL; | C3MX03, GCH3_SULIM; | C3NGF2, GCH3_SULIN; |
| C3N783, GCH3_SULIY; | Q980B6, GCH3_SULSO; | Q975M4, GCH3_SULTO; |
|
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