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ENZYME

ENZYME entry: EC 3.5.4.29

PURL: https://purl.expasy.org/enzyme/EC/3.5.4.29
Accepted Name
GTP cyclohydrolase IIa
Alternative Name(s)
GTP cyclohydrolase III
Reaction catalysed
GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 phosphate + 2 H(+)
Comment(s)
  • This enzyme catalyzes the hydrolysis of the imidazole ring of guanosine 5'-triphosphate, N(7)-methylguanosine 5'-triphosphate or inosine 5'-triphosphate.
  • Xanthosine 5'-triphosphate and ATP are not substrates.
  • It also catalyzes the hydrolysis of diphosphate to form two equivalents of phosphate.
  • Unlike EC 3.5.4.25, this enzyme does not release formate, but does hydrolyze the diphosphate from GTP to phosphate.
Cross-references
BRENDA3.5.4.29
EC2PDB3.5.4.29
ExplorEnz3.5.4.29
KEGG Ligand Database for Enzyme Nomenclature3.5.4.29
IUBMB Enzyme Nomenclature3.5.4.29
MEDLINEFind literature relating to 3.5.4.29
MetaCyc3.5.4.29
Rhea expert-curated reactions3.5.4.29
UniProtKB/Swiss-Prot
Q9HQT7, GCH31_HALSAQ9HQS9, GCH32_HALSAQ9YC89, GCH3_AERPE
B9LRB1, GCH3_HALLTQ57609, GCH3_METJAA4FZ97, GCH3_METM5
A9A6P4, GCH3_METM6A6VJ40, GCH3_METM7Q6M066, GCH3_METMP
A5ULV0, GCH3_METS3Q2NEH8, GCH3_METSTO27096, GCH3_METTH
A6US18, GCH3_METVSQ3INZ0, GCH3_NATPDQ8ZU20, GCH3_PYRAE
A4WKJ7, GCH3_PYRARA3MV81, GCH3_PYRCJA1RRI0, GCH3_PYRIL
B1YAW1, GCH3_PYRNVC3NGF2, GCH3_SACI1C3MR15, GCH3_SACI2
C3MZ63, GCH3_SACI3C3MX03, GCH3_SACI4C4KIE1, GCH3_SACI6
C3N783, GCH3_SACI7Q980B6, GCH3_SACS2Q975M4, GCH3_SULTO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-