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ENZYME entry: EC 3.5.4.29

Accepted Name
GTP cyclohydrolase IIa.
Alternative Name(s)
GTP cyclohydrolase III.
Reaction catalysed
GTP + 3 H(2)O <=> 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 phosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • This enzyme catalyzes the hydrolysis of the imidazole ring of guanosine 5'-triphosphate, N(7)-methylguanosine 5'-triphosphate or inosine 5'-triphosphate.
  • Xanthosine 5'-triphosphate and ATP are not substrates.
  • It also catalyzes the hydrolysis of diphosphate to form two equivalents of phosphate.
  • Unlike EC 3.5.4.25, this enzyme does not release formate, but does hydrolyze the diphosphate from GTP to phosphate.
Cross-references
BRENDA3.5.4.29
EC2PDB3.5.4.29
ExplorEnz3.5.4.29
PRIAM enzyme-specific profiles3.5.4.29
KEGG Ligand Database for Enzyme Nomenclature3.5.4.29
IUBMB Enzyme Nomenclature3.5.4.29
IntEnz3.5.4.29
MEDLINEFind literature relating to 3.5.4.29
MetaCyc3.5.4.29
Rhea expert-curated reactions3.5.4.29
UniProtKB/Swiss-Prot
Q9HQT7, GCH31_HALSA;  Q9HQS9, GCH32_HALSA;  Q9YC89, GCH3_AERPE;  
B9LRB1, GCH3_HALLT;  Q57609, GCH3_METJA;  A4FZ97, GCH3_METM5;  
A9A6P4, GCH3_METM6;  A6VJ40, GCH3_METM7;  Q6M066, GCH3_METMP;  
A5ULV0, GCH3_METS3;  Q2NEH8, GCH3_METST;  O27096, GCH3_METTH;  
A6US18, GCH3_METVS;  Q3INZ0, GCH3_NATPD;  Q8ZU20, GCH3_PYRAE;  
A4WKJ7, GCH3_PYRAR;  A3MV81, GCH3_PYRCJ;  A1RRI0, GCH3_PYRIL;  
B1YAW1, GCH3_PYRNV;  Q980B6, GCH3_SACS2;  C3MZ63, GCH3_SULIA;  
C4KIE1, GCH3_SULIK;  C3MR15, GCH3_SULIL;  C3MX03, GCH3_SULIM;  
C3NGF2, GCH3_SULIN;  C3N783, GCH3_SULIY;  Q975M4, GCH3_SULTO;  

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