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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.5.4.30

Accepted Name
dCTP deaminase (dUMP-forming).
Reaction catalysed
dCTP + 2 H(2)O <=> dUMP + diphosphate + NH(3)
Cofactor(s)
Mg(2+).
Comment(s)
  • Is highly specific for dCTP as substrate as dCMP, CTP, CDP, CMP, cytosine or deoxycytosine are not deaminated.
  • While most bacteria require two enzymes to form dUMP from dCTP (EC 3.5.4.13 and EC 3.6.1.23), the archaeon Methanocaldococcus jannaschii uses a single enzyme to carry out both functions.
  • This enzyme can also act as a dUTP diphosphatase, but more slowly.
Cross-references
BRENDA3.5.4.30
EC2PDB3.5.4.30
ExplorEnz3.5.4.30
PRIAM enzyme-specific profiles3.5.4.30
KEGG Ligand Database for Enzyme Nomenclature3.5.4.30
IUBMB Enzyme Nomenclature3.5.4.30
IntEnz3.5.4.30
MEDLINEFind literature relating to 3.5.4.30
MetaCyc3.5.4.30
UniProtKB/Swiss-Prot
A0LWS4, DCDB_ACIC1;  O67539, DCDB_AQUAE;  Q9KFV3, DCDB_BACHD;  
C5C4E1, DCDB_BEUC1;  B8DUY2, DCDB_BIFA0;  A1A3S8, DCDB_BIFAA;  
B3DP64, DCDB_BIFLD;  Q8G478, DCDB_BIFLO;  B7GPC4, DCDB_BIFLS;  
A5CV47, DCDB_CLAM3;  B0RD07, DCDB_CLAMS;  Q97N13, DCDB_CLOAB;  
A6M273, DCDB_CLOB8;  B2UWE6, DCDB_CLOBA;  B2TNM9, DCDB_CLOBB;  
A3DFH7, DCDB_CLOTH;  B5Y8K7, DCDB_COPPD;  Q6NEW7, DCDB_CORDI;  
Q8FM44, DCDB_COREF;  A4QHN8, DCDB_CORGB;  Q8NLT9, DCDB_CORGL;  
Q4JXY1, DCDB_CORJK;  C4LGU9, DCDB_CORK4;  Q11TJ6, DCDB_CYTH3;  
B5YB40, DCDB_DICT6;  B8DYK8, DCDB_DICTD;  A8LDU1, DCDB_FRASN;  
B8D0W3, DCDB_HALOH;  B0R2Y7, DCDB_HALS3;  Q9HSG3, DCDB_HALSA;  
Q9ZNJ8, DCDB_HATHI;  B4U7Y7, DCDB_HYDS0;  B2GGA3, DCDB_KOCRD;  
Q6AC71, DCDB_LEIXX;  B0SH49, DCDB_LEPBA;  Q04WA6, DCDB_LEPBJ;  
Q04X69, DCDB_LEPBL;  B0SQR4, DCDB_LEPBP;  Q72W72, DCDB_LEPIC;  
Q8F9W5, DCDB_LEPIN;  A6UWW5, DCDB_META3;  A7I6N9, DCDB_METB6;  
Q2FQM7, DCDB_METHJ;  Q57872, DCDB_METJA;  Q8TYK5, DCDB_METKA;  
A2SQW1, DCDB_METLZ;  A4FW98, DCDB_METM5;  A9A9N7, DCDB_METM6;  
A6VH12, DCDB_METM7;  A3CTK0, DCDB_METMJ;  Q6LXC6, DCDB_METMP;  
B8GHN1, DCDB_METPE;  A5UK79, DCDB_METS3;  Q2NFH1, DCDB_METST;  
O27875, DCDB_METTH;  A6UQ71, DCDB_METVS;  C5C6P4, DCDB_MICLC;  
A0QM15, DCDB_MYCA1;  Q7U297, DCDB_MYCBO;  A1KFE4, DCDB_MYCBP;  
C1AJZ9, DCDB_MYCBT;  A4T0X9, DCDB_MYCGI;  B8ZTC3, DCDB_MYCLB;  
Q9CB17, DCDB_MYCLE;  B2HP20, DCDB_MYCMM;  Q73T98, DCDB_MYCPA;  
A0QQ98, DCDB_MYCS2;  A3PTK2, DCDB_MYCSJ;  A1U9Z8, DCDB_MYCSK;  
Q1BEY3, DCDB_MYCSS;  A5TZ48, DCDB_MYCTA;  P9WP16, DCDB_MYCTO;  
P9WP17, DCDB_MYCTU;  A0PLM7, DCDB_MYCUA;  A1T2M8, DCDB_MYCVP;  
Q74MA7, DCDB_NANEQ;  Q5YNG0, DCDB_NOCFA;  A1SQ24, DCDB_NOCSJ;  
A1RAW1, DCDB_PAEAT;  C0QRW3, DCDB_PERMH;  B8H717, DCDB_PSECP;  
A9WT08, DCDB_RENSM;  C0ZSY9, DCDB_RHOE4;  Q0S5R4, DCDB_RHOJR;  
C1AWB6, DCDB_RHOOB;  A8LWH4, DCDB_SALAI;  A4X0Z1, DCDB_SALTO;  
Q82EZ9, DCDB_STRAW;  Q9X8W0, DCDB_STRCO;  B1VMF9, DCDB_STRGG;  
B2V937, DCDB_SULSY;  Q47KQ7, DCDB_THEFY;  Q83H71, DCDB_TROW8;  
Q820X8, DCDB_TROWT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
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