ID   3.5.99.14
DE   (S)-norcoclaurine synthase.
AN   (S)-norlaudanosoline synthase.
CA   (4-hydroxyphenyl)acetaldehyde + dopamine = (S)-norcoclaurine + H2O.
CC   -!- The reaction makes a six-membered ring by forming a bond between C-6
CC       of the 3,4-dihydroxyphenyl group of the dopamine and C-1 of the
CC       aldehyde in the imine formed between the substrates.
CC   -!- The product is the precursor of the benzylisoquinoline alkaloids in
CC       plants.
CC   -!- The enzyme, formerly known as (S)-norlaudanosoline synthase, will
CC       also catalyze the reaction of 4-(2-aminoethyl)benzene-1,2-diol +
CC       (3,4-dihydroxyphenyl)acetaldehyde to form (S)-norlaudanosoline,
CC       but this alkaloid has not been found to occur in plants.
CC   -!- Formerly EC 4.2.1.78.
DR   A2A1A0, NCS1_COPJA ;  Q4QTJ2, NCS1_PAPSO ;  A2A1A1, NCS2_COPJA ;
DR   Q4QTJ1, NCS2_PAPSO ;  Q67A25, NCS_THLFG  ;
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