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ENZYME

ENZYME entry: EC 3.5.99.6

Accepted Name
glucosamine-6-phosphate deaminase
Alternative Name(s)
GlcN6P deaminase
glucosamine-6-phosphate isomerase
glucosamine phosphate deaminase
phosphoglucosamine isomerase
phosphoglucosaminisomerase
Reaction catalysed
alpha-D-glucosamine 6-phosphate + H2O <=> beta-D-fructose 6-phosphate + NH4(+)
Comment(s)
  • Isomerization of the aldose-ketose type converts the -CH(-NH2)-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH2-OH, forming 2-deoxy-2-imino-D-arabino-hexitol which then hydrolyzes to yield fructose 6-phosphate and ammonia.
  • N-acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme.
  • Formerly EC 5.3.1.10.
Cross-references
BRENDA3.5.99.6
EC2PDB3.5.99.6
ExplorEnz3.5.99.6
PRIAM enzyme-specific profiles3.5.99.6
KEGG Ligand Database for Enzyme Nomenclature3.5.99.6
IUBMB Enzyme Nomenclature3.5.99.6
IntEnz3.5.99.6
MEDLINEFind literature relating to 3.5.99.6
MetaCyc3.5.99.6
Rhea expert-curated reactions3.5.99.6
UniProtKB/Swiss-Prot
A0KYQ7, AGAS_SHESAO31458, GAMA_BACSUQ5JDU3, GLMD_THEKO
A4FV08, GNPI1_BOVINO97439, GNPI1_GIAINP46926, GNPI1_HUMAN
Q64422, GNPI1_MESAUO88958, GNPI1_MOUSEQ5R8T8, GNPI1_PONAB
Q17QL1, GNPI2_BOVINO97440, GNPI2_GIAINQ8TDQ7, GNPI2_HUMAN
Q9CRC9, GNPI2_MOUSEQ6PA43, GNPI2_XENLAA4IHW6, GNPI2_XENTR
Q16HW7, GNPI_AEDAEQ5TNH5, GNPI_ANOGAQ9XVJ2, GNPI_CAEEL
Q54XK9, GNPI_DICDIQ9VMP9, GNPI_DROMEQ29NT9, GNPI_DROPS
Q04802, NAG1_CANALA9NEX8, NAGB_ACHLIA3N353, NAGB_ACTP2
B3GZ06, NAGB_ACTP7B0BSS6, NAGB_ACTPJA0KIG3, NAGB_AERHH
A4SPM2, NAGB_AERS4Q5E294, NAGB_ALIF1B5FBU7, NAGB_ALIFM
B6EN78, NAGB_ALISLQ5WHY0, NAGB_ALKCKA6TVP5, NAGB_ALKMQ
A8MIX7, NAGB_ALKOOA0JY49, NAGB_ARTS2C3P761, NAGB_BACAA
C3LIR9, NAGB_BACACA0RI59, NAGB_BACAHQ81MH5, NAGB_BACAN
B7JL33, NAGB_BACC0Q731P4, NAGB_BACC1B7IWG6, NAGB_BACC2
C1EQS8, NAGB_BACC3B7H945, NAGB_BACC4B7HN32, NAGB_BACC7
A7GS78, NAGB_BACCNB9IWR7, NAGB_BACCQQ819D1, NAGB_BACCR
Q635M6, NAGB_BACCZQ5LGU0, NAGB_BACFNQ64XP2, NAGB_BACFR
Q6HEB2, NAGB_BACHKA9VFF7, NAGB_BACMKA8FHS6, NAGB_BACP2
O35000, NAGB_BACSUQ8A094, NAGB_BACTNA7Z975, NAGB_BACVZ
C5BY94, NAGB_BEUC1B3DQQ9, NAGB_BIFLDQ8G4N5, NAGB_BIFLO
B7GQA1, NAGB_BIFLSQ7VR99, NAGB_BLOFLQ0SP13, NAGB_BORAP
O30564, NAGB_BORBUB7J183, NAGB_BORBZQ662L3, NAGB_BORGP
B2RZL5, NAGB_BORHDC0ZJF8, NAGB_BREBNQ8R5T0, NAGB_CALS4
B3PBV0, NAGB_CELJUA8AJE0, NAGB_CITK8Q97MK9, NAGB_CLOAB
A7FX73, NAGB_CLOB1C3L2N7, NAGB_CLOB6A6M241, NAGB_CLOB8
B2V163, NAGB_CLOBAB2TL69, NAGB_CLOBBA5I5R9, NAGB_CLOBH
C1FV12, NAGB_CLOBJB1IKY4, NAGB_CLOBKA7GH51, NAGB_CLOBL
B1KZ07, NAGB_CLOBMQ18AL0, NAGB_CLOD6A0PYW1, NAGB_CLONN
Q0TML8, NAGB_CLOP1Q8XHP8, NAGB_CLOPEQ0SQB4, NAGB_CLOPS
Q890L6, NAGB_CLOTEQ487K8, NAGB_COLP3C3PJW6, NAGB_CORA7
Q6NJ91, NAGB_CORDIQ8FMI6, NAGB_COREFA4QH44, NAGB_CORGB
Q8NMD4, NAGB_CORGLC4LL80, NAGB_CORK4B1VI88, NAGB_CORU7
A7MQT6, NAGB_CROS8Q6AAI8, NAGB_CUTAKA7ZJ60, NAGB_ECO24
B7UKV0, NAGB_ECO27B7MFT4, NAGB_ECO45B7L9L4, NAGB_ECO55
P0A760, NAGB_ECO57B5YQM0, NAGB_ECO5EB7NMM9, NAGB_ECO7I
B7MPI3, NAGB_ECO81B7M5J6, NAGB_ECO8AC4ZWF4, NAGB_ECOBW
B1X6L1, NAGB_ECODHA7ZXT7, NAGB_ECOHSA1A8T7, NAGB_ECOK1
Q0TK13, NAGB_ECOL5Q8FJX7, NAGB_ECOL6B1IY50, NAGB_ECOLC
P0A759, NAGB_ECOLIB7N9S4, NAGB_ECOLUB6HYN6, NAGB_ECOSE
B1LLC0, NAGB_ECOSMQ1REP9, NAGB_ECOUTC5BGA6, NAGB_EDWI9
A4W844, NAGB_ENT38P59687, NAGB_ENTFAB2VBN5, NAGB_ERWT9
B7LKT5, NAGB_ESCF3B1YJ30, NAGB_EXIS2C4L2C5, NAGB_EXISA
Q8REG1, NAGB_FUSNNC5D3L0, NAGB_GEOSWB8F877, NAGB_GLAP5
Q7VKN1, NAGB_HAEDUQ4QP46, NAGB_HAEI8A5UB10, NAGB_HAEIE
P44538, NAGB_HAEINQ2S6X5, NAGB_HAHCHQ9KFQ8, NAGB_HALH5
B8D185, NAGB_HALOHQ0I4B9, NAGB_HISS1B0UUN2, NAGB_HISS2
B5XZG9, NAGB_KLEP3A6T6C1, NAGB_KLEP7Q5FHT1, NAGB_LACAC
Q1G817, NAGB_LACDAQ047I3, NAGB_LACDBA8YTN8, NAGB_LACH4
Q74HC4, NAGB_LACJOQ9CFA8, NAGB_LACLAA2RJR7, NAGB_LACLM
Q02Y08, NAGB_LACLSQ033M5, NAGB_LACP3A9KIR8, NAGB_LACP7
Q88ZS6, NAGB_LACPLQ38YK9, NAGB_LATSSB1MX39, NAGB_LEUCK
Q03Z95, NAGB_LEUMMQ1WS60, NAGB_LIGS1A5VKB2, NAGB_LIMRD
Q92D64, NAGB_LISINC1L1M8, NAGB_LISMCQ721K9, NAGB_LISMF
B8DEH8, NAGB_LISMHQ8Y8E7, NAGB_LISMOA0AH75, NAGB_LISW6
B1HUU8, NAGB_LYSSCP59686, NAGB_LYSSHQ8EWM7, NAGB_MALP2
Q65QE8, NAGB_MANSMA6VVU9, NAGB_MARMSC6C0A2, NAGB_MARSD
Q6MSF4, NAGB_MYCMSQ98QJ9, NAGB_MYCPUA0QU88, NAGB_MYCS2
Q8ESL6, NAGB_OCEIHQ04G36, NAGB_OENOBA6LHV2, NAGB_PARD8
Q9CMF4, NAGB_PASMUQ6D7J9, NAGB_PECASC6DBY4, NAGB_PECCP
Q03H91, NAGB_PEDPAQ7MB61, NAGB_PHOLLA6L7Q8, NAGB_PHOV8
B2RJ01, NAGB_PORG3Q7MW43, NAGB_PORGIB4ESJ0, NAGB_PROMH
B8HAX3, NAGB_PSECPQ3ID09, NAGB_PSET1A1SS81, NAGB_PSYIN
Q7UVM5, NAGB_RHOBAQ0SGH6, NAGB_RHOJRC1AW66, NAGB_RHOOB
B5EZC1, NAGB_SALA4A9MKA9, NAGB_SALARQ57RQ0, NAGB_SALCH
B5FNB9, NAGB_SALDCB5QWC8, NAGB_SALEPB5R824, NAGB_SALG2
B4TB82, NAGB_SALHSB4SYN7, NAGB_SALNSQ5PCH6, NAGB_SALPA
A9MUG8, NAGB_SALPBC0PWA5, NAGB_SALPCB5BCC5, NAGB_SALPK
B4TPZ8, NAGB_SALSVQ8Z8G0, NAGB_SALTIQ8ZQX7, NAGB_SALTY
A8GB41, NAGB_SERP5B0TTP5, NAGB_SHEHHA3QB39, NAGB_SHELP
A8FRI2, NAGB_SHESHB1KFS0, NAGB_SHEWMB2TU53, NAGB_SHIB3
Q324M6, NAGB_SHIBSQ32IQ2, NAGB_SHIDSQ0T6S6, NAGB_SHIF8
P59688, NAGB_SHIFLQ3Z4C2, NAGB_SHISSA7WZ06, NAGB_STAA1
A6TZ46, NAGB_STAA2Q2FJ71, NAGB_STAA3Q2G0K8, NAGB_STAA8
A5IQC3, NAGB_STAA9Q2YS95, NAGB_STAABQ5HIA6, NAGB_STAAC
A6QEM2, NAGB_STAAEP65512, NAGB_STAAMP99125, NAGB_STAAN
Q6GJA0, NAGB_STAARQ6GBR8, NAGB_STAASA8YZR7, NAGB_STAAT
P65513, NAGB_STAAWQ5HRH8, NAGB_STAEQQ8CTR3, NAGB_STAES
Q4L9T8, NAGB_STAHJQ49VB6, NAGB_STAS1Q3K1Q7, NAGB_STRA1
P65514, NAGB_STRA3P65515, NAGB_STRA5P59689, NAGB_STRAW
Q9K487, NAGB_STRCOC0M970, NAGB_STRE4B4U206, NAGB_STREM
A8AYK4, NAGB_STRGCQ8DV70, NAGB_STRMUQ99Z50, NAGB_STRP1
Q04JT5, NAGB_STRP2P0DC66, NAGB_STRP3B5E5S3, NAGB_STRP4
Q5XBG4, NAGB_STRP6C1C814, NAGB_STRP7Q8P0E0, NAGB_STRP8
A2RDX6, NAGB_STRPGB1ICL5, NAGB_STRPIB8ZKX4, NAGB_STRPJ
Q97Q16, NAGB_STRPNP0DC67, NAGB_STRPQB5XM45, NAGB_STRPZ
Q8DPA1, NAGB_STRR6A4W0A3, NAGB_STRS2C0MCU1, NAGB_STRS7
A3CLX4, NAGB_STRSVA4VU11, NAGB_STRSYQ03LS1, NAGB_STRTD
B9DWG4, NAGB_STRU0C1CF03, NAGB_STRZJC1CLC3, NAGB_STRZP
C1CQU2, NAGB_STRZTB0K934, NAGB_THEP3B0K0J7, NAGB_THEPX
C4L889, NAGB_TOLATQ73QV6, NAGB_TREDEB7VTI0, NAGB_VIBA3
A7N5W3, NAGB_VIBC1A5F125, NAGB_VIBC3Q9KKS5, NAGB_VIBCH
C3LWT7, NAGB_VIBCMQ87K60, NAGB_VIBPAQ8D4T9, NAGB_VIBVU
Q7MGE1, NAGB_VIBVYA1JQE8, NAGB_YERE8A7FKU3, NAGB_YERP3
Q1C537, NAGB_YERPAB2K8A2, NAGB_YERPBQ8ZDE1, NAGB_YERPE
A9R7S4, NAGB_YERPGQ1CKN7, NAGB_YERPNA4TNY0, NAGB_YERPP
Q66DC7, NAGB_YERPSB1JG88, NAGB_YERPY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-