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ENZYME

ENZYME entry: EC 3.5.99.7

Accepted Name
1-aminocyclopropane-1-carboxylate deaminase
Alternative Name(s)
1-aminocyclopropane-1-carboxylate endolyase (deaminating)
1-aminocyclopropane carboxylic acid deaminase
ACC deaminase
Reaction catalysed
1-aminocyclopropane-1-carboxylate + H2O <=> 2-oxobutanoate + NH4(+)
Comment(s)
  • The enzyme, found in certain soil bacteria and fungi, catalyzes the ring opening of 1-aminocyclopropane-1-carboxylate, the immediate precursor to ethylene, an important plant hormone that regulates fruit ripening and other processes.
  • The enzyme releases an unstable enamine product that tautomerizes to an imine form, which undergoes spontaneous hydrolytic deamination.
  • The enzyme has been used to make fruit ripening dependent on externally added ethylene, as it removes the substrate for endogenous ethylene formation.
  • Formerly EC 4.1.99.4.
Cross-references
BRENDA3.5.99.7
EC2PDB3.5.99.7
ExplorEnz3.5.99.7
PRIAM enzyme-specific profiles3.5.99.7
KEGG Ligand Database for Enzyme Nomenclature3.5.99.7
IUBMB Enzyme Nomenclature3.5.99.7
IntEnz3.5.99.7
MEDLINEFind literature relating to 3.5.99.7
MetaCyc3.5.99.7
Rhea expert-curated reactions3.5.99.7
UniProtKB/Swiss-Prot
A1TVP2, 1A1D_ACIACB9MGI8, 1A1D_ACIETB9JJB7, 1A1D_AGRRK
B9K206, 1A1D_ALLAMQ89XR6, 1A1D_BRADUA5EJ46, 1A1D_BRASB
A4YUJ5, 1A1D_BRASOB1YYR8, 1A1D_BURA4A0AXI7, 1A1D_BURCH
B4EJA6, 1A1D_BURCJQ0B569, 1A1D_BURCMQ390Z5, 1A1D_BURL3
A9AQJ3, 1A1D_BURM1A3ME84, 1A1D_BURM7A2RWH4, 1A1D_BURM9
Q62CE3, 1A1D_BURMAA1UVN3, 1A1D_BURMSB1K774, 1A1D_BURO0
Q1BL32, 1A1D_BURO1A3P669, 1A1D_BURP0Q3JLQ0, 1A1D_BURP1
A3NKK4, 1A1D_BURP6Q63KN7, 1A1D_BURPSQ2T6A1, 1A1D_BURTA
A4JKV8, 1A1D_BURVGQ5KMX3, 1A1D_CRYNJQ0K1H0, 1A1D_CUPNH
Q7M523, 1A1D_CYBSAQ9ZHW3, 1A1D_ENTCLB8IP05, 1A1D_METNO
A2SLW2, 1A1D_METPPB0UGM0, 1A1D_METS4B2TBV3, 1A1D_PARPJ
Q13ME5, 1A1D_PARXLQ48KS9, 1A1D_PSE14Q51813, 1A1D_PSEFL
Q5PWZ8, 1A1D_PSEPUP30297, 1A1D_PSES0Q87YW7, 1A1D_PSESM
Q4ZVH4, 1A1D_PSEU2Q00740, 1A1D_PSEUDQ9V2L2, 1A1D_PYRAB
Q8U4R3, 1A1D_PYRFUO57809, 1A1D_PYRHOQ8XS35, 1A1D_RALN1
B2UGM5, 1A1D_RALPJQ98AM7, 1A1D_RHILOQ93AG0, 1A1D_RHILV
Q9AHF0, 1A1D_RHIRDQ9URX3, 1A1D_SCHPOQ9WY68, 1A1D_THEMA
Q6J256, 1A1D_VARPDC5CQC9, 1A1D_VARPSF4HYF3, DCYD1_ARATH

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